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• W2040890014 startingPage "e113745" @default.
• W2040890014 abstract "CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation. Cxxc1-null mouse embryos fail to gastrulate, and Cxxc1-null embryonic stem cells are viable but cannot differentiate, suggesting that Cfp1 is required for chromatin remodeling associated with stem cell differentiation and embryogenesis. Mice homozygous for a conditional Cxxc1 deletion allele and carrying the inducible Mx1-Cre transgene were generated to assess Cfp1 function in adult animals. Induction of Cre expression in adult animals led to Cfp1 depletion in hematopoietic cells, a failure of hematopoiesis with a nearly complete loss of lineage-committed progenitors and mature cells, elevated levels of apoptosis, and death within two weeks. A similar pathology resulted following transplantation of conditional Cxxc1 bone marrow cells into wild type recipients, demonstrating this phenotype is intrinsic to Cfp1 function within bone marrow cells. Remarkably, the Lin−Sca-1+c-Kit+ population of cells in the bone marrow, which is enriched for hematopoietic stem cells and multi-potential progenitor cells, persists and expands in the absence of Cfp1 during this time frame. Thus, Cfp1 is necessary for hematopoietic stem and multi-potential progenitor cell function and for the developmental potential of differentiating hematopoietic cells." @default.
• W2040890014 created "2016-06-24" @default.
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• W2040890014 date "2014-12-03" @default.
• W2040890014 modified "2023-10-15" @default.
• W2040890014 title "The Epigenetic Regulator CXXC Finger Protein 1 is Essential for Murine Hematopoiesis" @default.
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• W2040890014 doi "https://doi.org/10.1371/journal.pone.0113745" @default.
• W2040890014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4254612" @default.
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