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- W2040890697 abstract "The presence of fetal fibronectin (FFN) in vaginal fluid is associated with risk for spontaneous preterm birth (SPTB). The effect of serial FFN samples on risk for SPTB is not known. We hypothesized that FFN status over gestation collected on serial exams is informative with respect to risk of SPTB <36wks for women with a short cervix (CL<25mm). This is a secondary analysis of a multicenter prospective observational cohort study designed to study predictors of preterm birth. Women with singleton gestation from the general obstetric population had CL ultrasounds and vaginal FFN detection performed at intervals of 2 weeks between 20-33wks gestation. The relation between FFN status and SPTB was evaluated using logistic regression. 2721 women had CL exams and serially collected FFN. 412 (15.1%) women had CL<25mm and 2309 (84.9%) had CL ≥25mm. We evaluated FFN status at two visits: visit 1 [median 23.9 weeks(range 28-28 weeks)] and visit 2 [median 28.1 weeks (range 25-33 weeks)]. FFN positivity was associated with SPTB at visits 1 and 2 for women with CL <25mm (OR 2.3 and 5.4, respectively, p<0.01 for both) and for visit 2 for women with CL ≥25mm (OR 1.9, p<0.01). Odds ratios for SPTB by FFN status over gestation are shown in the Table for CL<25mm. The association was present when controlling for age, race, BMI, and tobacco use. Risk for SPTB in women with CL<25mm and a history of prior preterm birth (n=88) was further increased. There was no association between FFN status over gestation and SPTB for women with CL≥25mm.Tabled 1FFN statusFFN1FFN2CL<25 adjOR (95%CI)CL<25 + prior SPTB adjOR (95%CI)1−−RefRef2+−2.5 (1.01-6.34)3.0 (0.6-14.5)3−+6.5 (3.0-14.0)20.1 (2.4-169.3)4++9.2 (2.8-20.9)6.7 (0.65-68.3) Open table in a new tab Among women with a sonographically short cervix, FFN status assessed over two time points is informative with respect to risk of subsequent SPTB. The findings of this study support the need for prospective studies to evaluate the role of serial collection of FFN among women identified as having a sonographically short cervix." @default.
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- W2040890697 date "2011-01-01" @default.
- W2040890697 modified "2023-09-27" @default.
- W2040890697 title "504: Serial collection of fetal fibronectin and the risk of spontaneous preterm birth among women with a sonographically short cervix" @default.
- W2040890697 doi "https://doi.org/10.1016/j.ajog.2010.10.523" @default.
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