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- W2040890762 abstract "Although inhaled nitric oxide (INO) and high frequency oscillatory ventilation (HFOV) are effective therapies in severe persistent pulmonary hypertension of the newborn (PPHN), the efficacy of these therapies in neonates with sepsis and PPHN are unknown. To determine the response rate to INO and HFOV and to identify factors associated with poor responses in septic newborns we analyzed the data from a multicenter trial of INO and HFOV in neonates with PPHN. Criteria for enrollment included: gestational age ≥ 34 weeks, Pa02 60 torr led to treatment with the alternative or combined therapy (INO+HFOV). Of 205 neonates enrolled in this study, 22 were identified as septic by blood culture (20 with group B strep). Eleven infants improved and survived without ECMO(Responders). Of the eleven responders, 4 responded to INO, 3 responded to HFOV, 4 required INO and HFOV. Eleven infants did not respond and were treated with ECMO (N=8 with 5 deaths)or died without ECMO (N=3). There were no differences in AaD02 and blood pressure between responders and non-responders at study entry. However, non-responders had lower pH (7.43±.08 vs. 7.13±.19,P 7.31 at study entry responded and 100% survived without ECMO. We conclude that: 1. septic newborns with severe PPHN have a 50% response rate to treatment strategies which include INO and HFOV; 2. non-response to these therapies is associated with high mortality (73%) despite ECMO therapy; and 3. metabolic acidosis is a marker of poor responsiveness." @default.
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- W2040890762 date "1997-04-01" @default.
- W2040890762 modified "2023-10-18" @default.
- W2040890762 title "Response to inhaled nitric oxide and high frequency oscillatory ventilation in septic newborns with severe pulmonary hypertension. † 1618" @default.
- W2040890762 doi "https://doi.org/10.1203/00006450-199704001-01637" @default.
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