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- W2040891502 abstract "FoxO3a is a member of the forkhead box class O (FoxO) transcription factor family and an important regulator of apoptosis. This work aimed to elucidate the involvement of FoxO3a in transforming growth factor-<TEX>${beta}1$</TEX>(TGF-<TEX>${beta}1$</TEX>)-induced apoptosis in FaO rat hepatoma cells. TGF-<TEX>${beta}1$</TEX> caused a time-dependent activation of FoxO3a and a subsequent increase in FoxO response-element-containing luciferase reporter activity, which was Akt-sensitive. The FaO cells stably transfected with a wild type FoxO3a were more susceptible to the formation of apoptotic bodies, populations of sub-G1 apoptotic cells, and collapse of the mitochondrial-membrane potential triggered by TGF-<TEX>${beta}1$</TEX>. In contrast, transfection with small-interfering RNA (siRNA) oligonucleotide specific for FoxO3a significantly inhibited caspase activation in FaO cells treated with TGF-<TEX>${beta}1$</TEX>. It thus appears that FoxO3a plays a crucial mediatory role in the TGF-<TEX>${beta}1$</TEX> signaling pathway leading to apoptosis." @default.
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- W2040891502 date "2008-10-31" @default.
- W2040891502 modified "2023-09-26" @default.
- W2040891502 title "FoxO3a mediates transforming growth factor-β1-induced apoptosis in FaO rat hepatoma cells" @default.
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- W2040891502 doi "https://doi.org/10.5483/bmbrep.2008.41.10.728" @default.
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