FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040892290> ?p ?o ?g. }

• W2040892290 endingPage "604" @default.
• W2040892290 startingPage "593" @default.
• W2040892290 abstract "Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and nature of cell signaling events. Confluent endothelial cells are contact inhibited in their growth and respond poorly to the proliferative signals of vascular endothelial growth factor (VEGF). In a previous study, we found that the association of vascular endothelial cadherin (VEC) with VEGF receptor (VEGFR) type 2 contributes to density-dependent growth inhibition (Lampugnani, G.M., A. Zanetti, M. Corada, T. Takahashi, G. Balconi, F. Breviario, F. Orsenigo, A. Cattelino, R. Kemler, T.O. Daniel, and E. Dejana. 2003. J. Cell Biol. 161:793-804). In the present study, we describe the mechanism through which VEC reduces VEGFR-2 signaling. We found that VEGF induces the clathrin-dependent internalization of VEGFR-2. When VEC is absent or not engaged at junctions, VEGFR-2 is internalized more rapidly and remains in endosomal compartments for a longer time. Internalization does not terminate its signaling; instead, the internalized receptor is phosphorylated, codistributes with active phospholipase C-gamma, and activates p44/42 mitogen-activated protein kinase phosphorylation and cell proliferation. Inhibition of VEGFR-2 internalization reestablishes the contact inhibition of cell growth, whereas silencing the junction-associated density-enhanced phosphatase-1/CD148 phosphatase restores VEGFR-2 internalization and signaling. Thus, VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments." @default.
• W2040892290 created "2016-06-24" @default.
• W2040892290 creator A5001922604 @default.
• W2040892290 creator A5003887782 @default.
• W2040892290 creator A5020394757 @default.
• W2040892290 creator A5027971423 @default.
• W2040892290 creator A5072674760 @default.
• W2040892290 date "2006-08-07" @default.
• W2040892290 modified "2023-10-11" @default.
• W2040892290 title "Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments" @default.
• W2040892290 cites W1532288573 @default.
• W2040892290 cites W1967532587 @default.
• W2040892290 cites W1968323673 @default.
• W2040892290 cites W1974556922 @default.
• W2040892290 cites W1974955986 @default.
• W2040892290 cites W1982912692 @default.
• W2040892290 cites W1987558313 @default.
• W2040892290 cites W1992101966 @default.
• W2040892290 cites W1993547614 @default.
• W2040892290 cites W1993562474 @default.
• W2040892290 cites W1996219643 @default.
• W2040892290 cites W1999956350 @default.
• W2040892290 cites W2003870055 @default.
• W2040892290 cites W2014263971 @default.
• W2040892290 cites W2017201573 @default.
• W2040892290 cites W2020166810 @default.
• W2040892290 cites W2025383253 @default.
• W2040892290 cites W2032930150 @default.
• W2040892290 cites W2036832250 @default.
• W2040892290 cites W2040283898 @default.
• W2040892290 cites W2046525214 @default.
• W2040892290 cites W2050893164 @default.
• W2040892290 cites W2051338141 @default.
• W2040892290 cites W2053959232 @default.
• W2040892290 cites W2057292369 @default.
• W2040892290 cites W2065550467 @default.
• W2040892290 cites W2067005574 @default.
• W2040892290 cites W2082315732 @default.
• W2040892290 cites W2083017733 @default.
• W2040892290 cites W2084740377 @default.
• W2040892290 cites W2085126643 @default.
• W2040892290 cites W2087890701 @default.
• W2040892290 cites W2088925802 @default.
• W2040892290 cites W2105998706 @default.
• W2040892290 cites W2106789666 @default.
• W2040892290 cites W2114354954 @default.
• W2040892290 cites W2115569175 @default.
• W2040892290 cites W2116628576 @default.
• W2040892290 cites W2127186963 @default.
• W2040892290 cites W2127442452 @default.
• W2040892290 cites W2129087010 @default.
• W2040892290 cites W2134767876 @default.
• W2040892290 cites W2136418873 @default.
• W2040892290 cites W2140469576 @default.
• W2040892290 cites W2140699138 @default.
• W2040892290 cites W2143358669 @default.
• W2040892290 cites W2144026946 @default.
• W2040892290 cites W2145993183 @default.
• W2040892290 cites W2147176626 @default.
• W2040892290 cites W2148286539 @default.
• W2040892290 cites W2148464651 @default.
• W2040892290 cites W2148700019 @default.
• W2040892290 cites W2158950529 @default.
• W2040892290 cites W2161246942 @default.
• W2040892290 cites W2165169147 @default.
• W2040892290 cites W2167703034 @default.
• W2040892290 cites W2265183803 @default.
• W2040892290 cites W2346001310 @default.
• W2040892290 cites W4241779034 @default.
• W2040892290 cites W4903968 @default.
• W2040892290 doi "https://doi.org/10.1083/jcb.200602080" @default.
• W2040892290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064264" @default.
• W2040892290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16893970" @default.
• W2040892290 hasPublicationYear "2006" @default.
• W2040892290 type Work @default.
• W2040892290 sameAs 2040892290 @default.
• W2040892290 citedByCount "482" @default.
• W2040892290 countsByYear W20408922902012 @default.
• W2040892290 countsByYear W20408922902013 @default.
• W2040892290 countsByYear W20408922902014 @default.
• W2040892290 countsByYear W20408922902015 @default.
• W2040892290 countsByYear W20408922902016 @default.
• W2040892290 countsByYear W20408922902017 @default.
• W2040892290 countsByYear W20408922902018 @default.
• W2040892290 countsByYear W20408922902019 @default.
• W2040892290 countsByYear W20408922902020 @default.
• W2040892290 countsByYear W20408922902021 @default.
• W2040892290 countsByYear W20408922902022 @default.
• W2040892290 countsByYear W20408922902023 @default.
• W2040892290 crossrefType "journal-article" @default.
• W2040892290 hasAuthorship W2040892290A5001922604 @default.
• W2040892290 hasAuthorship W2040892290A5003887782 @default.
• W2040892290 hasAuthorship W2040892290A5020394757 @default.
• W2040892290 hasAuthorship W2040892290A5027971423 @default.
• W2040892290 hasAuthorship W2040892290A5072674760 @default.
• W2040892290 hasBestOaLocation W20408922901 @default.
• W2040892290 hasConcept C102747710 @default.
• W2040892290 hasConcept C11960822 @default.

• next