FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040892836> ?p ?o ?g. }

• W2040892836 endingPage "22" @default.
• W2040892836 startingPage "15" @default.
• W2040892836 abstract "Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a clinically relevant pathogen because of its resistance to antibiotics and its ability to form potent biofilm. Both ica-negative as well as ica-positive MRSA strains are known to produce biofilm. In the present study, these strains were grown in biofilm mode and susceptibility of these to antibiotics was assessed. Our study suggests that antibiotic susceptibility of MRSA biofilm depends on the biochemical composition of its matrix. The biofilm matrix of ica-positive MRSA was mainly composed of poly-intercellular adhesion (PIA), whereas eDNA was a major constituent of ica-negative MRSA. The results showed that MRSA in planktonic growth was susceptible to clindamycin, vancomycin and minocycline. However, the MIC and MBC of vancomycin for the mature biofilm of ica-negative MRSA was 16 and 32 μg ml(-1), respectively. On the contrary, the MIC and MBC of vancomycin for ica-positive MRSA was >1024 μg ml(-1). The effect of vancomycin and minocycline on young and old biofilms was also determined. Vancomycin was quite effective in eradicating the young biofilm formed by ica-negative MRSA; however, it was completely ineffective on the biofilm of ica-positive MRSA. Minocycline at its highest clinical achievable concentration was found to be quite effective in eradicating the young biofilm formed by both the strains. The enzyme-linked immunosorbent assay (ELISA) results and dot blot assay suggest that the presence of ica locus influenced PIA production, which probably contributed towards the failure of vancomycin in eradicating the biofilm formed by ica-positive strain. However, none of the antibiotics used in this study was effective in eradicating the mature biofilms." @default.
• W2040892836 created "2016-06-24" @default.
• W2040892836 creator A5017859649 @default.
• W2040892836 creator A5019242629 @default.
• W2040892836 creator A5084166974 @default.
• W2040892836 date "2014-07-30" @default.
• W2040892836 modified "2023-10-14" @default.
• W2040892836 title "Antibiotic susceptibility of ica-positive and ica-negative MRSA in different phases of biofilm growth" @default.
• W2040892836 cites W1562607772 @default.
• W2040892836 cites W1985326161 @default.
• W2040892836 cites W1995611257 @default.
• W2040892836 cites W1997245990 @default.
• W2040892836 cites W2002165055 @default.
• W2040892836 cites W2015098730 @default.
• W2040892836 cites W2017821807 @default.
• W2040892836 cites W2021530734 @default.
• W2040892836 cites W2026109440 @default.
• W2040892836 cites W2033136871 @default.
• W2040892836 cites W2033457495 @default.
• W2040892836 cites W2039258127 @default.
• W2040892836 cites W2042503394 @default.
• W2040892836 cites W2054412355 @default.
• W2040892836 cites W2061878956 @default.
• W2040892836 cites W2083592242 @default.
• W2040892836 cites W2091564013 @default.
• W2040892836 cites W2096274970 @default.
• W2040892836 cites W2098785211 @default.
• W2040892836 cites W2106351298 @default.
• W2040892836 cites W2106538205 @default.
• W2040892836 cites W2108433768 @default.
• W2040892836 cites W2114144364 @default.
• W2040892836 cites W2121955511 @default.
• W2040892836 cites W2129361538 @default.
• W2040892836 cites W2130577876 @default.
• W2040892836 cites W2131237419 @default.
• W2040892836 cites W2131534333 @default.
• W2040892836 cites W2132577709 @default.
• W2040892836 cites W2152761448 @default.
• W2040892836 cites W2155464395 @default.
• W2040892836 cites W2156879228 @default.
• W2040892836 cites W2163463398 @default.
• W2040892836 cites W2166739522 @default.
• W2040892836 cites W2168482920 @default.
• W2040892836 cites W4252771679 @default.
• W2040892836 cites W4253391147 @default.
• W2040892836 doi "https://doi.org/10.1038/ja.2014.96" @default.
• W2040892836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25074658" @default.
• W2040892836 hasPublicationYear "2014" @default.
• W2040892836 type Work @default.
• W2040892836 sameAs 2040892836 @default.
• W2040892836 citedByCount "26" @default.
• W2040892836 countsByYear W20408928362015 @default.
• W2040892836 countsByYear W20408928362016 @default.
• W2040892836 countsByYear W20408928362017 @default.
• W2040892836 countsByYear W20408928362018 @default.
• W2040892836 countsByYear W20408928362019 @default.
• W2040892836 countsByYear W20408928362021 @default.
• W2040892836 countsByYear W20408928362022 @default.
• W2040892836 countsByYear W20408928362023 @default.
• W2040892836 crossrefType "journal-article" @default.
• W2040892836 hasAuthorship W2040892836A5017859649 @default.
• W2040892836 hasAuthorship W2040892836A5019242629 @default.
• W2040892836 hasAuthorship W2040892836A5084166974 @default.
• W2040892836 hasBestOaLocation W20408928361 @default.
• W2040892836 hasConcept C2777052132 @default.
• W2040892836 hasConcept C2778275353 @default.
• W2040892836 hasConcept C2778980435 @default.
• W2040892836 hasConcept C2779489039 @default.
• W2040892836 hasConcept C501593827 @default.
• W2040892836 hasConcept C523546767 @default.
• W2040892836 hasConcept C54355233 @default.
• W2040892836 hasConcept C58123911 @default.
• W2040892836 hasConcept C86803240 @default.
• W2040892836 hasConcept C89423630 @default.
• W2040892836 hasConceptScore W2040892836C2777052132 @default.
• W2040892836 hasConceptScore W2040892836C2778275353 @default.
• W2040892836 hasConceptScore W2040892836C2778980435 @default.
• W2040892836 hasConceptScore W2040892836C2779489039 @default.
• W2040892836 hasConceptScore W2040892836C501593827 @default.
• W2040892836 hasConceptScore W2040892836C523546767 @default.
• W2040892836 hasConceptScore W2040892836C54355233 @default.
• W2040892836 hasConceptScore W2040892836C58123911 @default.
• W2040892836 hasConceptScore W2040892836C86803240 @default.
• W2040892836 hasConceptScore W2040892836C89423630 @default.
• W2040892836 hasIssue "1" @default.
• W2040892836 hasLocation W20408928361 @default.
• W2040892836 hasLocation W20408928362 @default.
• W2040892836 hasOpenAccess W2040892836 @default.
• W2040892836 hasPrimaryLocation W20408928361 @default.
• W2040892836 hasRelatedWork W1116104845 @default.
• W2040892836 hasRelatedWork W2037263811 @default.
• W2040892836 hasRelatedWork W2382345126 @default.
• W2040892836 hasRelatedWork W2620220220 @default.
• W2040892836 hasRelatedWork W26546154 @default.
• W2040892836 hasRelatedWork W2980009902 @default.
• W2040892836 hasRelatedWork W2997146492 @default.
• W2040892836 hasRelatedWork W3135879499 @default.
• W2040892836 hasRelatedWork W3190033734 @default.

• next