FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040893034> ?p ?o ?g. }

• W2040893034 endingPage "565" @default.
• W2040893034 startingPage "555" @default.
• W2040893034 abstract "Abstract Toll‐like receptor ( TLR )‐mediated signalling plays a role in cerebral ischaemia/reperfusion (I/R) injury. Modulation of TLR s has been reported to protect against cerebral I/R injury. This study examined whether modulation of TLR 3 with poly (I:C) will induce protection against cerebral I/R injury. Mice were treated with or without Poly (I:C) ( n = 8/group) 1 hr prior to cerebral ischaemia (60 min.) followed by reperfusion (24 hrs). Poly (I:C) pre‐treatment significantly reduced the infarct volume by 57.2% compared with untreated I/R mice. Therapeutic administration of Poly (I:C), administered 30 min. after cerebral ischaemia, markedly decreased infarct volume by 34.9%. However, Poly (I:C)‐induced protection was lost in TLR 3 knockout mice. In poly (I:C)‐treated mice, there was less neuronal damage in the hippocampus compared with untreated I/R mice. Poly (I:C) treatment induced IRF 3 phosphorylation, but it inhibited NF ‐κB activation in the brain. Poly (I:C) also decreased I/R‐induced apoptosis by attenuation of Fas/FasL‐mediated apoptotic signalling. In addition, Poly (I:C) treatment decreased microglial cell caspase‐3 activity. In vitro data showed that Poly (I:C) prevented hypoxia/reoxygenation (H/R)‐induced interaction between Fas and FADD as well as caspase‐3 and ‐8 activation in microglial cells. Importantly, Poly (I:C) treatment induced co‐association between TLR 3 and Fas. Our data suggest that Poly (I:C) decreases in cerebral I/R injury via TLR 3 which associates with Fas, thereby preventing the interaction of Fas and FADD , as well as microglial cell caspase‐3 and ‐8 activities. We conclude that TLR 3 modulation by Poly (I:C) could be a potential approach for protection against ischaemic stroke." @default.
• W2040893034 created "2016-06-24" @default.
• W2040893034 creator A5010221465 @default.
• W2040893034 creator A5024414501 @default.
• W2040893034 creator A5028927398 @default.
• W2040893034 creator A5033677559 @default.
• W2040893034 creator A5058503442 @default.
• W2040893034 creator A5063481044 @default.
• W2040893034 creator A5069653639 @default.
• W2040893034 creator A5071074966 @default.
• W2040893034 creator A5086436451 @default.
• W2040893034 creator A5090875147 @default.
• W2040893034 date "2014-10-29" @default.
• W2040893034 modified "2023-10-07" @default.
• W2040893034 title "Poly (I:C) therapy decreases cerebral ischaemia/reperfusion injury <i>via </i><scp>TLR</scp>3‐mediated prevention of Fas/<scp>FADD</scp> interaction" @default.
• W2040893034 cites W1498166809 @default.
• W2040893034 cites W1551533003 @default.
• W2040893034 cites W1556892705 @default.
• W2040893034 cites W1919531607 @default.
• W2040893034 cites W1930598094 @default.
• W2040893034 cites W1963508865 @default.
• W2040893034 cites W1968026156 @default.
• W2040893034 cites W1969448809 @default.
• W2040893034 cites W1976010325 @default.
• W2040893034 cites W1977935404 @default.
• W2040893034 cites W1984391988 @default.
• W2040893034 cites W1985419968 @default.
• W2040893034 cites W1986308149 @default.
• W2040893034 cites W1998732967 @default.
• W2040893034 cites W2004201665 @default.
• W2040893034 cites W2016575029 @default.
• W2040893034 cites W2019070297 @default.
• W2040893034 cites W2021008015 @default.
• W2040893034 cites W2029357279 @default.
• W2040893034 cites W2044964980 @default.
• W2040893034 cites W2045098547 @default.
• W2040893034 cites W2050681503 @default.
• W2040893034 cites W2065549997 @default.
• W2040893034 cites W2076034559 @default.
• W2040893034 cites W2077306969 @default.
• W2040893034 cites W2078150553 @default.
• W2040893034 cites W2080424756 @default.
• W2040893034 cites W2085477318 @default.
• W2040893034 cites W2091080691 @default.
• W2040893034 cites W2103278596 @default.
• W2040893034 cites W2108388278 @default.
• W2040893034 cites W2109445380 @default.
• W2040893034 cites W2114855685 @default.
• W2040893034 cites W2124667416 @default.
• W2040893034 cites W2130421043 @default.
• W2040893034 cites W2134940821 @default.
• W2040893034 cites W2135814466 @default.
• W2040893034 cites W2141677575 @default.
• W2040893034 cites W2152073406 @default.
• W2040893034 cites W2156895352 @default.
• W2040893034 cites W2160524354 @default.
• W2040893034 cites W2165413779 @default.
• W2040893034 cites W2167090083 @default.
• W2040893034 cites W2463052500 @default.
• W2040893034 cites W2614781785 @default.
• W2040893034 doi "https://doi.org/10.1111/jcmm.12456" @default.
• W2040893034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4369813" @default.
• W2040893034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25351293" @default.
• W2040893034 hasPublicationYear "2014" @default.
• W2040893034 type Work @default.
• W2040893034 sameAs 2040893034 @default.
• W2040893034 citedByCount "25" @default.
• W2040893034 countsByYear W20408930342014 @default.
• W2040893034 countsByYear W20408930342015 @default.
• W2040893034 countsByYear W20408930342016 @default.
• W2040893034 countsByYear W20408930342017 @default.
• W2040893034 countsByYear W20408930342018 @default.
• W2040893034 countsByYear W20408930342019 @default.
• W2040893034 countsByYear W20408930342020 @default.
• W2040893034 countsByYear W20408930342021 @default.
• W2040893034 countsByYear W20408930342022 @default.
• W2040893034 countsByYear W20408930342023 @default.
• W2040893034 crossrefType "journal-article" @default.
• W2040893034 hasAuthorship W2040893034A5010221465 @default.
• W2040893034 hasAuthorship W2040893034A5024414501 @default.
• W2040893034 hasAuthorship W2040893034A5028927398 @default.
• W2040893034 hasAuthorship W2040893034A5033677559 @default.
• W2040893034 hasAuthorship W2040893034A5058503442 @default.
• W2040893034 hasAuthorship W2040893034A5063481044 @default.
• W2040893034 hasAuthorship W2040893034A5069653639 @default.
• W2040893034 hasAuthorship W2040893034A5071074966 @default.
• W2040893034 hasAuthorship W2040893034A5086436451 @default.
• W2040893034 hasAuthorship W2040893034A5090875147 @default.
• W2040893034 hasBestOaLocation W20408930341 @default.
• W2040893034 hasConcept C126322002 @default.
• W2040893034 hasConcept C178790620 @default.
• W2040893034 hasConcept C185592680 @default.
• W2040893034 hasConcept C190283241 @default.
• W2040893034 hasConcept C203014093 @default.
• W2040893034 hasConcept C2776055636 @default.
• W2040893034 hasConcept C2780114680 @default.
• W2040893034 hasConcept C31573885 @default.
• W2040893034 hasConcept C540031477 @default.

• next