Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040893569> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2040893569 endingPage "415" @default.
- W2040893569 startingPage "413" @default.
- W2040893569 abstract "The idea of an effective and safe medical treatment that is also noninvasive and preferably outpatient has undisputed appeal to patients diagnosed with symptomatic ureterolithiasis who wish to eliminate their stones as rapidly as possible. Such a treatment has been the object of intensive basic and clinical research for more than a decade and has been identified in what is now referred to as medical expulsive therapy (MET). MET is part of the established therapeutic armamentarium for ureteric calculi alongside observation, shock wave lithotripsy, ureteroscopy, and ureterolithotomy [1]. MET developed from several physiologic and pathophysiologic premises. The ureter is lined by smoothmuscle cells that respond to variations in calcium ion concentrations. An increase in calcium levels causes ureteric muscle contraction, whilst a decrease determines relaxation [2]. Furthermore, smooth muscle cells are densely populated with a-1-adrenergic receptors, especially in the distal third of the ureter. Receptor blockade inhibits basal smooth muscle tone and hyperperistaltic uncoordinated frequency whilst maintaining tonic propulsive contractions [3]. Calculi may induce ureteric spasms that interfere with calculi expulsion; thus, muscle relaxation with maintenance of normal antegrade peristaltic activity may facilitate passage. Finally, it has been shown that larger calculi particularly tend to provoke intense inflammatory changes in the ureteric wall and that submucosal oedema in proximity to a stone may worsen ureteric obstruction, heightening the risk of impaction and retention [4]. Researchers have therefore sought substances that are capable of either relaxing the ureteric wall or preventing mucosal oedema, albeit the exact dynamics of ureteric" @default.
- W2040893569 created "2016-06-24" @default.
- W2040893569 creator A5024021311 @default.
- W2040893569 creator A5050834286 @default.
- W2040893569 date "2009-09-01" @default.
- W2040893569 modified "2023-10-18" @default.
- W2040893569 title "Recommending Medical Expulsive Therapy for Distal Ureteric Calculi: A Step Back?" @default.
- W2040893569 cites W1979021308 @default.
- W2040893569 cites W1980609418 @default.
- W2040893569 cites W1984520738 @default.
- W2040893569 cites W1992116300 @default.
- W2040893569 cites W1998551755 @default.
- W2040893569 cites W2039308124 @default.
- W2040893569 cites W2054075819 @default.
- W2040893569 cites W2057354586 @default.
- W2040893569 cites W2067443585 @default.
- W2040893569 cites W2068600746 @default.
- W2040893569 cites W2075824635 @default.
- W2040893569 cites W2111323078 @default.
- W2040893569 cites W2113457301 @default.
- W2040893569 cites W2123520542 @default.
- W2040893569 cites W2132633916 @default.
- W2040893569 cites W2135148556 @default.
- W2040893569 cites W2135968239 @default.
- W2040893569 doi "https://doi.org/10.1016/j.eururo.2009.04.044" @default.
- W2040893569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19427108" @default.
- W2040893569 hasPublicationYear "2009" @default.
- W2040893569 type Work @default.
- W2040893569 sameAs 2040893569 @default.
- W2040893569 citedByCount "7" @default.
- W2040893569 countsByYear W20408935692012 @default.
- W2040893569 countsByYear W20408935692013 @default.
- W2040893569 countsByYear W20408935692014 @default.
- W2040893569 countsByYear W20408935692017 @default.
- W2040893569 crossrefType "journal-article" @default.
- W2040893569 hasAuthorship W2040893569A5024021311 @default.
- W2040893569 hasAuthorship W2040893569A5050834286 @default.
- W2040893569 hasConcept C126894567 @default.
- W2040893569 hasConcept C141071460 @default.
- W2040893569 hasConcept C71924100 @default.
- W2040893569 hasConceptScore W2040893569C126894567 @default.
- W2040893569 hasConceptScore W2040893569C141071460 @default.
- W2040893569 hasConceptScore W2040893569C71924100 @default.
- W2040893569 hasIssue "3" @default.
- W2040893569 hasLocation W20408935691 @default.
- W2040893569 hasLocation W20408935692 @default.
- W2040893569 hasOpenAccess W2040893569 @default.
- W2040893569 hasPrimaryLocation W20408935691 @default.
- W2040893569 hasRelatedWork W2002120878 @default.
- W2040893569 hasRelatedWork W2003938723 @default.
- W2040893569 hasRelatedWork W2047967234 @default.
- W2040893569 hasRelatedWork W2118496982 @default.
- W2040893569 hasRelatedWork W2364998975 @default.
- W2040893569 hasRelatedWork W2369162477 @default.
- W2040893569 hasRelatedWork W2439875401 @default.
- W2040893569 hasRelatedWork W4238867864 @default.
- W2040893569 hasRelatedWork W2519357708 @default.
- W2040893569 hasRelatedWork W2525756941 @default.
- W2040893569 hasVolume "56" @default.
- W2040893569 isParatext "false" @default.
- W2040893569 isRetracted "false" @default.
- W2040893569 magId "2040893569" @default.
- W2040893569 workType "article" @default.