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- W2040894120 abstract "We review statistical-mechanical theories of single-molecule micromanipulation experiments on nucleic acids. Firstly, models for describing polymer elasticity are introduced. We then review how these models are used to interpret single-molecule force-extension experiments on single-stranded and double-stranded DNA. Depending on the force and the molecules used, both smooth elastic behavior and abrupt structural transitions are observed. Thirdly, we show how combining the elasticity of two single nucleic acid strands with a description of the base-pairing interactions between them explains much of the phenomenology and kinetics of RNA and DNA ‘unzipping’ experiments. To cite this article: S. Cocco et al., C. R. Physique 3 (2002) 569–584. Les travaux théoriques portant sur les expériences sur molécules uniques sont ici passés en revue. Tout d'abord, nous introduisons les modèles simples de polymères élastiques. Ensuite, nous expliquons comment ces modèles peuvent être utilisés pour interpréter les mesures de force-extension effectuées sur une molécule unique d'ADN (simple brin ou double brin), mesures qui mettent en évidence tantôt le caractère élastique de cette molécule, tantôt des transitions structurelles brutales. Dans une troisième partie, nous montrons qu'en associant les propriétes élastiques des brins d'acides nucléiques à une description de leurs interactions d'appariement, l'essentiel de la phénomènologie et de la cinétique de dégraffage de l'ARN et l'ADN peut être expliqué. Pour citer cet article : S. Cocco et al., C. R. Physique 3 (2002) 569–584." @default.
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- W2040894120 date "2002-01-01" @default.
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- W2040894120 title "Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping" @default.
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- W2040894120 doi "https://doi.org/10.1016/s1631-0705(02)01345-2" @default.
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