FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040897181> ?p ?o ?g. }

• W2040897181 endingPage "689" @default.
• W2040897181 startingPage "683" @default.
• W2040897181 abstract "A promising approach to reduce the impact of influenza is the use of an attenuated, live virus as a vaccine. Using reverse genetics, we generated a mutant of strain A/WSN/33 with a modified cleavage site within its hemagglutinin, which depends on proteolytic activation by elastase. Unlike the wild-type, which requires trypsin, this mutant is strictly dependent on elastase. Both viruses grow equally well in cell culture. In contrast to the lethal wild-type virus, the mutant is entirely attenuated in mice. At a dose of 10(5) plaque-forming units, it induced complete protection against lethal challenge. This approach allows the conversion of any epidemic strain into a genetically homologous attenuated virus." @default.
• W2040897181 created "2016-06-24" @default.
• W2040897181 creator A5016895449 @default.
• W2040897181 creator A5017296714 @default.
• W2040897181 creator A5020871813 @default.
• W2040897181 creator A5058177872 @default.
• W2040897181 creator A5072405396 @default.
• W2040897181 date "2005-05-29" @default.
• W2040897181 modified "2023-10-18" @default.
• W2040897181 title "A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin" @default.
• W2040897181 cites W193865296 @default.
• W2040897181 cites W1967946497 @default.
• W2040897181 cites W1978330686 @default.
• W2040897181 cites W1980823976 @default.
• W2040897181 cites W1982057650 @default.
• W2040897181 cites W1982110386 @default.
• W2040897181 cites W1987266434 @default.
• W2040897181 cites W1988725751 @default.
• W2040897181 cites W1993047642 @default.
• W2040897181 cites W2004582162 @default.
• W2040897181 cites W2013184461 @default.
• W2040897181 cites W2013453931 @default.
• W2040897181 cites W2013529043 @default.
• W2040897181 cites W2018594295 @default.
• W2040897181 cites W2021101853 @default.
• W2040897181 cites W2037794003 @default.
• W2040897181 cites W2052139590 @default.
• W2040897181 cites W2052746833 @default.
• W2040897181 cites W2069651570 @default.
• W2040897181 cites W2070706666 @default.
• W2040897181 cites W2082446596 @default.
• W2040897181 cites W2083546895 @default.
• W2040897181 cites W2083824307 @default.
• W2040897181 cites W2087933112 @default.
• W2040897181 cites W2091527885 @default.
• W2040897181 cites W2092150602 @default.
• W2040897181 cites W2111170944 @default.
• W2040897181 cites W2123679254 @default.
• W2040897181 cites W2133106116 @default.
• W2040897181 cites W2134787952 @default.
• W2040897181 cites W2136830567 @default.
• W2040897181 cites W2142040409 @default.
• W2040897181 cites W2171968687 @default.
• W2040897181 cites W2302882406 @default.
• W2040897181 cites W2314791685 @default.
• W2040897181 cites W2329421968 @default.
• W2040897181 cites W4237236497 @default.
• W2040897181 doi "https://doi.org/10.1038/nm1256" @default.
• W2040897181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15924146" @default.
• W2040897181 hasPublicationYear "2005" @default.
• W2040897181 type Work @default.
• W2040897181 sameAs 2040897181 @default.
• W2040897181 citedByCount "83" @default.
• W2040897181 countsByYear W20408971812012 @default.
• W2040897181 countsByYear W20408971812013 @default.
• W2040897181 countsByYear W20408971812014 @default.
• W2040897181 countsByYear W20408971812015 @default.
• W2040897181 countsByYear W20408971812017 @default.
• W2040897181 countsByYear W20408971812018 @default.
• W2040897181 countsByYear W20408971812019 @default.
• W2040897181 countsByYear W20408971812020 @default.
• W2040897181 countsByYear W20408971812021 @default.
• W2040897181 countsByYear W20408971812022 @default.
• W2040897181 countsByYear W20408971812023 @default.
• W2040897181 crossrefType "journal-article" @default.
• W2040897181 hasAuthorship W2040897181A5016895449 @default.
• W2040897181 hasAuthorship W2040897181A5017296714 @default.
• W2040897181 hasAuthorship W2040897181A5020871813 @default.
• W2040897181 hasAuthorship W2040897181A5058177872 @default.
• W2040897181 hasAuthorship W2040897181A5072405396 @default.
• W2040897181 hasBestOaLocation W20408971811 @default.
• W2040897181 hasConcept C104317684 @default.
• W2040897181 hasConcept C143065580 @default.
• W2040897181 hasConcept C151730666 @default.
• W2040897181 hasConcept C159047783 @default.
• W2040897181 hasConcept C175156509 @default.
• W2040897181 hasConcept C207583985 @default.
• W2040897181 hasConcept C2522874641 @default.
• W2040897181 hasConcept C25365240 @default.
• W2040897181 hasConcept C2777546802 @default.
• W2040897181 hasConcept C2778692840 @default.
• W2040897181 hasConcept C2781416681 @default.
• W2040897181 hasConcept C43369102 @default.
• W2040897181 hasConcept C54355233 @default.
• W2040897181 hasConcept C54602769 @default.
• W2040897181 hasConcept C60987743 @default.
• W2040897181 hasConcept C86803240 @default.
• W2040897181 hasConcept C89423630 @default.
• W2040897181 hasConceptScore W2040897181C104317684 @default.
• W2040897181 hasConceptScore W2040897181C143065580 @default.
• W2040897181 hasConceptScore W2040897181C151730666 @default.
• W2040897181 hasConceptScore W2040897181C159047783 @default.
• W2040897181 hasConceptScore W2040897181C175156509 @default.
• W2040897181 hasConceptScore W2040897181C207583985 @default.
• W2040897181 hasConceptScore W2040897181C2522874641 @default.
• W2040897181 hasConceptScore W2040897181C25365240 @default.
• W2040897181 hasConceptScore W2040897181C2777546802 @default.
• W2040897181 hasConceptScore W2040897181C2778692840 @default.

• next