FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040897855> ?p ?o ?g. }

• W2040897855 endingPage "783" @default.
• W2040897855 startingPage "769" @default.
• W2040897855 abstract "The accurate prediction of the secondary and tertiary structure of an RNA with different folding algorithms is dependent on several factors, including the energy functions. However, an RNA higher-order structure cannot be predicted accurately from its sequence based on a limited set of energy parameters. The inter- and intramolecular forces between this RNA and other small molecules and macromolecules, in addition to other factors in the cell such as pH, ionic strength, and temperature, influence the complex dynamics associated with transition of a single stranded RNA to its secondary and tertiary structure. Since all of the factors that affect the formation of an RNAs 3D structure cannot be determined experimentally, statistically derived potential energy has been used in the prediction of protein structure. In the current work, we evaluate the statistical free energy of various secondary structure motifs, including base-pair stacks, hairpin loops, and internal loops, using their statistical frequency obtained from the comparative analysis of more than 50,000 RNA sequences stored in the RNA Comparative Analysis Database (rCAD) at the Comparative RNA Web (CRW) Site. Statistical energy was computed from the structural statistics for several datasets. While the statistical energy for a base-pair stack correlates with experimentally derived free energy values, suggesting a Boltzmann-like distribution, variation is observed between different molecules and their location on the phylogenetic tree of life. Our statistical energy values calculated for several structural elements were utilized in the Mfold RNA-folding algorithm. The combined statistical energy values for base-pair stacks, hairpins and internal loop flanks result in a significant improvement in the accuracy of secondary structure prediction; the hairpin flanks contribute the most." @default.
• W2040897855 created "2016-06-24" @default.
• W2040897855 creator A5002772328 @default.
• W2040897855 creator A5013890468 @default.
• W2040897855 creator A5014867905 @default.
• W2040897855 creator A5037723295 @default.
• W2040897855 creator A5085204570 @default.
• W2040897855 date "2009-08-01" @default.
• W2040897855 modified "2023-10-09" @default.
• W2040897855 title "Correlation of RNA Secondary Structure Statistics with Thermodynamic Stability and Applications to Folding" @default.
• W2040897855 cites W1489623410 @default.
• W2040897855 cites W1559047570 @default.
• W2040897855 cites W1967538502 @default.
• W2040897855 cites W1970739926 @default.
• W2040897855 cites W1978988830 @default.
• W2040897855 cites W1980056776 @default.
• W2040897855 cites W1985124981 @default.
• W2040897855 cites W1988380385 @default.
• W2040897855 cites W1988409793 @default.
• W2040897855 cites W1990847911 @default.
• W2040897855 cites W1994900806 @default.
• W2040897855 cites W1994958179 @default.
• W2040897855 cites W1995065087 @default.
• W2040897855 cites W1999613945 @default.
• W2040897855 cites W2000406179 @default.
• W2040897855 cites W2001916877 @default.
• W2040897855 cites W2002502414 @default.
• W2040897855 cites W2006461920 @default.
• W2040897855 cites W2007592156 @default.
• W2040897855 cites W2009818318 @default.
• W2040897855 cites W2012268010 @default.
• W2040897855 cites W2013902881 @default.
• W2040897855 cites W2017838368 @default.
• W2040897855 cites W2023206235 @default.
• W2040897855 cites W2024412145 @default.
• W2040897855 cites W2026486846 @default.
• W2040897855 cites W2029503078 @default.
• W2040897855 cites W2035783320 @default.
• W2040897855 cites W2038070375 @default.
• W2040897855 cites W2045895660 @default.
• W2040897855 cites W2050367846 @default.
• W2040897855 cites W2051188149 @default.
• W2040897855 cites W2051706390 @default.
• W2040897855 cites W2051713039 @default.
• W2040897855 cites W2053568821 @default.
• W2040897855 cites W2053695683 @default.
• W2040897855 cites W2053742705 @default.
• W2040897855 cites W2057850636 @default.
• W2040897855 cites W2058334701 @default.
• W2040897855 cites W2061384728 @default.
• W2040897855 cites W2068725534 @default.
• W2040897855 cites W2075121899 @default.
• W2040897855 cites W2085158278 @default.
• W2040897855 cites W2087101377 @default.
• W2040897855 cites W2087862352 @default.
• W2040897855 cites W2088979606 @default.
• W2040897855 cites W2089549574 @default.
• W2040897855 cites W2090375359 @default.
• W2040897855 cites W2091778154 @default.
• W2040897855 cites W2098271534 @default.
• W2040897855 cites W2102017611 @default.
• W2040897855 cites W2102914911 @default.
• W2040897855 cites W2104533058 @default.
• W2040897855 cites W2112935159 @default.
• W2040897855 cites W2115729502 @default.
• W2040897855 cites W2127313259 @default.
• W2040897855 cites W2130479394 @default.
• W2040897855 cites W2135300233 @default.
• W2040897855 cites W2136989186 @default.
• W2040897855 cites W2137640371 @default.
• W2040897855 cites W2138167486 @default.
• W2040897855 cites W2140957135 @default.
• W2040897855 cites W2143705059 @default.
• W2040897855 cites W2143726250 @default.
• W2040897855 cites W2157006452 @default.
• W2040897855 cites W2159548583 @default.
• W2040897855 cites W2165810116 @default.
• W2040897855 cites W2396589048 @default.
• W2040897855 cites W4230118546 @default.
• W2040897855 doi "https://doi.org/10.1016/j.jmb.2009.06.036" @default.
• W2040897855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2778063" @default.
• W2040897855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19540243" @default.
• W2040897855 hasPublicationYear "2009" @default.
• W2040897855 type Work @default.
• W2040897855 sameAs 2040897855 @default.
• W2040897855 citedByCount "26" @default.
• W2040897855 countsByYear W20408978552012 @default.
• W2040897855 countsByYear W20408978552013 @default.
• W2040897855 countsByYear W20408978552015 @default.
• W2040897855 countsByYear W20408978552016 @default.
• W2040897855 countsByYear W20408978552018 @default.
• W2040897855 countsByYear W20408978552020 @default.
• W2040897855 countsByYear W20408978552022 @default.
• W2040897855 crossrefType "journal-article" @default.
• W2040897855 hasAuthorship W2040897855A5002772328 @default.
• W2040897855 hasAuthorship W2040897855A5013890468 @default.
• W2040897855 hasAuthorship W2040897855A5014867905 @default.
• W2040897855 hasAuthorship W2040897855A5037723295 @default.

• next