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• W2040903539 startingPage "e66816" @default.
• W2040903539 abstract "According to the developmental origins of health and diseases (DOHaD), and in line with the findings of many studies, obesity during pregnancy is clearly a threat to the health and well-being of the offspring, later in adulthood. We previously showed that 20% of male and female inbred mice can cope with the obesogenic effects of a high-fat diet (HFD) for 20 weeks after weaning, remaining lean. However the feeding of a control diet (CD) to DIO mice during the periconceptional/gestation/lactation period led to a pronounced sex-specific shift (17% to 43%) from susceptibility to resistance to HFD, in the female offspring only. Our aim in this study was to determine how, in the context of maternal obesity and T2D, a CD could increase resistance on female fetuses. Transcriptional analyses were carried out with a custom-built mouse liver microarray and by quantitative RT-PCR for muscle and adipose tissue. Both global DNA methylation and levels of pertinent histone marks were assessed by LUMA and western blotting, and the expression of 15 relevant genes encoding chromatin-modifying enzymes was analyzed in tissues presenting global epigenetic changes. Resistance was associated with an enhancement of hepatic pathways protecting against steatosis, the unexpected upregulation of neurotransmission-related genes and the modulation of a vast imprinted gene network. Adipose tissue displayed a pronounced dysregulation of gene expression, with an upregulation of genes involved in lipid storage and adipocyte hypertrophy or hyperplasia in obese mice born to lean and obese mothers, respectively. Global DNA methylation, several histone marks and key epigenetic regulators were also altered. Whether they were themselves lean (resistant) or obese (sensitive), the offspring of lean and obese mice clearly differed in terms of several metabolic features and epigenetic marks suggesting that the effects of a HFD depend on the leanness or obesity of the mother." @default.
• W2040903539 created "2016-06-24" @default.
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• W2040903539 date "2013-06-24" @default.
• W2040903539 modified "2023-10-18" @default.
• W2040903539 title "Dietary Alleviation of Maternal Obesity and Diabetes: Increased Resistance to Diet-Induced Obesity Transcriptional and Epigenetic Signatures" @default.
• W2040903539 cites W1495791931 @default.
• W2040903539 cites W1563149938 @default.
• W2040903539 cites W1577577364 @default.
• W2040903539 cites W1739793538 @default.
• W2040903539 cites W1915547574 @default.
• W2040903539 cites W1931341579 @default.
• W2040903539 cites W1932533342 @default.
• W2040903539 cites W1954666192 @default.
• W2040903539 cites W1966429292 @default.
• W2040903539 cites W1976015869 @default.
• W2040903539 cites W1989854187 @default.
• W2040903539 cites W1990609945 @default.
• W2040903539 cites W1996374391 @default.
• W2040903539 cites W1999835438 @default.
• W2040903539 cites W2005089034 @default.
• W2040903539 cites W2005271716 @default.
• W2040903539 cites W2005406769 @default.
• W2040903539 cites W2007523563 @default.
• W2040903539 cites W2011920499 @default.
• W2040903539 cites W2014135861 @default.
• W2040903539 cites W2021803200 @default.
• W2040903539 cites W2024886887 @default.
• W2040903539 cites W2025920043 @default.
• W2040903539 cites W2034714209 @default.
• W2040903539 cites W2037841634 @default.
• W2040903539 cites W2044616072 @default.
• W2040903539 cites W2046262003 @default.
• W2040903539 cites W2049662858 @default.
• W2040903539 cites W2051834155 @default.
• W2040903539 cites W2052528853 @default.
• W2040903539 cites W2056744634 @default.
• W2040903539 cites W2061060395 @default.
• W2040903539 cites W2063301376 @default.
• W2040903539 cites W2063525732 @default.
• W2040903539 cites W2067248033 @default.
• W2040903539 cites W2071510932 @default.
• W2040903539 cites W2071875898 @default.
• W2040903539 cites W2085975528 @default.
• W2040903539 cites W2089111792 @default.
• W2040903539 cites W2090651683 @default.
• W2040903539 cites W2092603991 @default.
• W2040903539 cites W2093483466 @default.
• W2040903539 cites W2095312889 @default.
• W2040903539 cites W2099160667 @default.
• W2040903539 cites W2099696895 @default.
• W2040903539 cites W2103368550 @default.
• W2040903539 cites W2105952005 @default.
• W2040903539 cites W2114688343 @default.
• W2040903539 cites W2117121254 @default.
• W2040903539 cites W2117183312 @default.
• W2040903539 cites W2123021448 @default.
• W2040903539 cites W2123735783 @default.
• W2040903539 cites W2125618313 @default.
• W2040903539 cites W2127925508 @default.
• W2040903539 cites W2130330362 @default.
• W2040903539 cites W2137372228 @default.
• W2040903539 cites W2138143575 @default.
• W2040903539 cites W2140498210 @default.
• W2040903539 cites W2141200407 @default.
• W2040903539 cites W2143770547 @default.
• W2040903539 cites W2144720261 @default.
• W2040903539 cites W2145226640 @default.
• W2040903539 cites W2149097469 @default.
• W2040903539 cites W2150272037 @default.
• W2040903539 cites W2151484167 @default.
• W2040903539 cites W2153604445 @default.
• W2040903539 cites W2153876418 @default.
• W2040903539 cites W2154428470 @default.
• W2040903539 cites W2155804510 @default.
• W2040903539 cites W2157038986 @default.
• W2040903539 cites W2162169788 @default.
• W2040903539 cites W2162303623 @default.
• W2040903539 cites W2163002796 @default.
• W2040903539 cites W2168526937 @default.
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• W2040903539 doi "https://doi.org/10.1371/journal.pone.0066816" @default.
• W2040903539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3691260" @default.
• W2040903539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23826145" @default.
• W2040903539 hasPublicationYear "2013" @default.
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