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• W2040907078 abstract "The contribution of calmodulin to the effects of Cd(2+) on microtubules has been investigated in the detergent-extracted cytoskeletons of cultured cells and on tubulin polymerization in vitro. When incubated with micromolar concentrations of Cd(2+) or Ca(2+) alone, or a mixture of both ions, microtubules in the extracted cytoskeletons disassembled. This disassembly was prevented by compound 48/80, a potent calmodulin inhibitor. In bovine brain microtubule protein containing microtubule-associated proteins, calmodulin also enhanced the Cd(2+)-mediated inhibition of tubulin polymerization; further, this enhancing effect of calmodulin was reversed by compound 48/80. These results demonstrate that Cd(2+) can affect microtubules by binding to and activating calmodulin." @default.
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• W2040907078 date "1989-01-01" @default.
• W2040907078 modified "2023-09-27" @default.
• W2040907078 title "Calmodulin modulation of adverse effects of Cd2+ on microtubules and tubulin polymerization in vitro" @default.
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• W2040907078 doi "https://doi.org/10.1016/0887-2333(89)90010-6" @default.
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