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- W2040909256 abstract "Chromaffin granules, the secretory vesicles of the adrenal medulla, are stable in isotonic sucrose solutions at room temperature; however, when low concentrations of the ionophore A23187 are added, rapid lysis ensues which is dependent on the presence of a divalent cation chelator and is prevented by the addition of either Ca2+ or Mg2+. As little as 10μM Ca2+ totally inhibit lysis of chromaffin granules by A23187, while 28 mM KCl have no effect. Lysis by A23187 at 4.7 μM is almost 100% in the presence of EDTA in isotonic sucrose in 1 h and can be suppressed by raising the osmotic strength of the medium with half maximal inhibition at 0.57 M sucrose, demonstrating that A23187 causes osmotic lysis of chromaffin granules as a consequence of the withdrawal of divalent cations from the core solution. Our results strongly suggest that divalent cations are involved in the formation of a ionic complex in the core solution which lowers its effective osmotic pressure." @default.
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- W2040909256 title "Evidence for a divalent cation dependent catecholamine storage complex in chromaffin granules" @default.
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- W2040909256 doi "https://doi.org/10.1016/0006-291x(83)90576-4" @default.
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