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- W2040919076 abstract "In view of the probability that clostripain (EC 3,4,22.8) is fundamentally different in structure from other known cysteine endopeptidases. It was of interest to examine the characteristics of the active site Z‐Pho‐Lys‐CH 2 S(CH 3 ) 2 irreversibly and rapidly inactivated clostripain, and leupeptin was found to be the most potent reversible inhibitor yet reported for the enzyme. Clostripain was inhibited weakly by some protein inhibitors of serine endopeptidases, and required Ca + for stability and activity. Mg 2+ and Sr 2+ were ineffective. Rapid inactivation by diethylpyrocarbonate, reversed by hydroxylamine, indicated that histidine is essential for catalytic activity. Clostripain was more rapidly inactivated by iodoacetamide than by iodoacetate, with unique pH‐dependences or reaction." @default.
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- W2040919076 date "1991-06-03" @default.
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- W2040919076 title "Clostripain: Characterization of the active site" @default.
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- W2040919076 doi "https://doi.org/10.1016/0014-5793(91)80607-5" @default.
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