Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040931483> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2040931483 abstract "Root bark extracts from Zanthoxylum zanthoxyloides Lam (Rutaceae) and Calotropis procera Aït (Asclepiadaceae) were used in Burkina Faso folk medicine for several diseases particularly sickle cell anemia. Authors reported here vasorelaxant effect of these plants on rat isolated aorta. Z. zanthoxyloïdes (cumulative addition) produces a concentration-dependent relaxation on the aorta. Maximal effects are respectively of 60.34 ± 2.34 and 100% in the presence and in the absence of endothelium. C. procera extract induces a more relaxing effect on endothelium-denuded aorta (Emax = 59.78 ± 2.13% and 100% in presence and absence of endothelium respectively). FACA, the mixture of these two plants also induces vasorelaxation (Emax = 100%), with better effect in the presence of endothelium (EC50 = 2.76 ± 0.38 mg/mL and 4.90 ± 0.69 mg/mL in presence and absence of endothelium respectively). Endothelium-dependent vasodilator effect of FACA was inhibited by L-NAME; this clearly indicates that NO is involved in aorta relaxation process by FACA. Taken together this study revealed that FACA and its components possess vasodilator effect. This vascular property of FACA may be involved in the amendment of sickle cell crisis through inhibition of vaso-occlusion process.Keywords: Sickle cell anemia, phytotherapy, rat aorta, endothelium" @default.
- W2040931483 created "2016-06-24" @default.
- W2040931483 creator A5041459917 @default.
- W2040931483 creator A5047305140 @default.
- W2040931483 creator A5056647027 @default.
- W2040931483 creator A5067550461 @default.
- W2040931483 creator A5078852184 @default.
- W2040931483 creator A5082407584 @default.
- W2040931483 date "2012-05-04" @default.
- W2040931483 modified "2023-10-01" @default.
- W2040931483 title "Vasodilator effect of <em>Zanthoxylum zanthoxyloïdes, Calotropis procera</em> and FACA, a mixture of these two plants" @default.
- W2040931483 doi "https://doi.org/10.4314/ijbcs.v5i4.1" @default.
- W2040931483 hasPublicationYear "2012" @default.
- W2040931483 type Work @default.
- W2040931483 sameAs 2040931483 @default.
- W2040931483 citedByCount "1" @default.
- W2040931483 countsByYear W20409314832017 @default.
- W2040931483 crossrefType "journal-article" @default.
- W2040931483 hasAuthorship W2040931483A5041459917 @default.
- W2040931483 hasAuthorship W2040931483A5047305140 @default.
- W2040931483 hasAuthorship W2040931483A5056647027 @default.
- W2040931483 hasAuthorship W2040931483A5067550461 @default.
- W2040931483 hasAuthorship W2040931483A5078852184 @default.
- W2040931483 hasAuthorship W2040931483A5082407584 @default.
- W2040931483 hasBestOaLocation W20409314831 @default.
- W2040931483 hasConcept C120770815 @default.
- W2040931483 hasConcept C126322002 @default.
- W2040931483 hasConcept C185592680 @default.
- W2040931483 hasConcept C2776992346 @default.
- W2040931483 hasConcept C2779406593 @default.
- W2040931483 hasConcept C2779980429 @default.
- W2040931483 hasConcept C556039675 @default.
- W2040931483 hasConcept C71924100 @default.
- W2040931483 hasConcept C86803240 @default.
- W2040931483 hasConcept C98274493 @default.
- W2040931483 hasConceptScore W2040931483C120770815 @default.
- W2040931483 hasConceptScore W2040931483C126322002 @default.
- W2040931483 hasConceptScore W2040931483C185592680 @default.
- W2040931483 hasConceptScore W2040931483C2776992346 @default.
- W2040931483 hasConceptScore W2040931483C2779406593 @default.
- W2040931483 hasConceptScore W2040931483C2779980429 @default.
- W2040931483 hasConceptScore W2040931483C556039675 @default.
- W2040931483 hasConceptScore W2040931483C71924100 @default.
- W2040931483 hasConceptScore W2040931483C86803240 @default.
- W2040931483 hasConceptScore W2040931483C98274493 @default.
- W2040931483 hasIssue "4" @default.
- W2040931483 hasLocation W20409314831 @default.
- W2040931483 hasOpenAccess W2040931483 @default.
- W2040931483 hasPrimaryLocation W20409314831 @default.
- W2040931483 hasRelatedWork W1981264646 @default.
- W2040931483 hasRelatedWork W2029692170 @default.
- W2040931483 hasRelatedWork W2040931483 @default.
- W2040931483 hasRelatedWork W2045247784 @default.
- W2040931483 hasRelatedWork W2046188881 @default.
- W2040931483 hasRelatedWork W2317054360 @default.
- W2040931483 hasRelatedWork W2348024989 @default.
- W2040931483 hasRelatedWork W2362812864 @default.
- W2040931483 hasRelatedWork W3104644448 @default.
- W2040931483 hasRelatedWork W3143899041 @default.
- W2040931483 hasVolume "5" @default.
- W2040931483 isParatext "false" @default.
- W2040931483 isRetracted "false" @default.
- W2040931483 magId "2040931483" @default.
- W2040931483 workType "article" @default.