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• W2040933166 abstract "Changes in synapse structure occur in frontal neocortex with HIV encephalitis (HIVE) and may contribute to HIV-associated neurocognitive disorders (HAND). A postmortem survey was conducted to determine if mRNAs involved in synaptic transmission are perturbed in dorsolateral prefrontal cortex (DLPFC) in subjects with HIVE or HAND. Expression of the opioid neurotransmitter preproenkephalin mRNA (PENK) was significantly decreased in a sampling of 446 brain specimens from HIV-1 infected people compared to 67 HIV negative subjects. Decreased DLPFC PENK was most evident in subjects with HIVE and/or increased expression of interferon regulatory factor 1 mRNA (IRF1). Type 2 dopamine receptor mRNA (DRD2L) was decreased significantly, but not in the same set of subjects with PENK dysregulation. DRD2L downregulation occurred primarily in the subjects without HIVE or neurocognitive impairment. Subjects with neurocognitive impairment often failed to significantly downregulate DRD2L and had abnormally high IRF1 expression.Dysregulation of synaptic preproenkephalin and DRD2L in frontal neocortex can occur with and without neurocognitive impairment in HIV-infected people. Downregulation of DRD2L in the prefrontal cortex was associated with more favorable neuropsychological and neuropathological outcomes; the failure to downregulate DRD2L was significantly less favorable. PENK downregulation was related neuropathologically to HIVE, but was not related to neuropsychological outcome independently. Emulating endogenous synaptic plasticity pharmacodynamically could enhance synaptic accommodation and improve neuropsychological and neuropathological outcomes in HIV/AIDS." @default.
• W2040933166 created "2016-06-24" @default.
• W2040933166 creator A5029652042 @default.
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• W2040933166 date "2012-03-06" @default.
• W2040933166 modified "2023-10-14" @default.
• W2040933166 title "Prefrontal Dopaminergic and Enkephalinergic Synaptic Accommodation in HIV-associated Neurocognitive Disorders and Encephalitis" @default.
• W2040933166 cites W103311651 @default.
• W2040933166 cites W1482335491 @default.
• W2040933166 cites W1527753734 @default.
• W2040933166 cites W1542136448 @default.
• W2040933166 cites W1596515083 @default.
• W2040933166 cites W1761073303 @default.
• W2040933166 cites W1857277871 @default.
• W2040933166 cites W1948168563 @default.
• W2040933166 cites W1963705583 @default.
• W2040933166 cites W1964186052 @default.
• W2040933166 cites W1964372429 @default.
• W2040933166 cites W1971243166 @default.
• W2040933166 cites W1971681588 @default.
• W2040933166 cites W1972044687 @default.
• W2040933166 cites W1973371295 @default.
• W2040933166 cites W1973503789 @default.
• W2040933166 cites W1976789367 @default.
• W2040933166 cites W1976895949 @default.
• W2040933166 cites W1979190471 @default.
• W2040933166 cites W1980530615 @default.
• W2040933166 cites W1985156573 @default.
• W2040933166 cites W1987362442 @default.
• W2040933166 cites W1989369404 @default.
• W2040933166 cites W1989790828 @default.
• W2040933166 cites W1990131415 @default.
• W2040933166 cites W1990445317 @default.
• W2040933166 cites W1991603311 @default.
• W2040933166 cites W1991688849 @default.
• W2040933166 cites W1995746794 @default.
• W2040933166 cites W1995924099 @default.
• W2040933166 cites W1997231957 @default.
• W2040933166 cites W2002132239 @default.
• W2040933166 cites W2003119451 @default.
• W2040933166 cites W2006240651 @default.
• W2040933166 cites W2007010563 @default.
• W2040933166 cites W2008697344 @default.
• W2040933166 cites W2010891174 @default.
• W2040933166 cites W2012865678 @default.
• W2040933166 cites W2013105800 @default.
• W2040933166 cites W2013870111 @default.
• W2040933166 cites W2019278705 @default.
• W2040933166 cites W2026634146 @default.
• W2040933166 cites W2032124268 @default.
• W2040933166 cites W2032866243 @default.
• W2040933166 cites W2032885541 @default.
• W2040933166 cites W2033274431 @default.
• W2040933166 cites W2033410859 @default.
• W2040933166 cites W2035418780 @default.
• W2040933166 cites W2035872135 @default.
• W2040933166 cites W2037012882 @default.
• W2040933166 cites W2037210922 @default.
• W2040933166 cites W2038418633 @default.
• W2040933166 cites W2039603323 @default.
• W2040933166 cites W2041132533 @default.
• W2040933166 cites W2041504972 @default.
• W2040933166 cites W2042441113 @default.
• W2040933166 cites W2042625194 @default.
• W2040933166 cites W2043315694 @default.
• W2040933166 cites W2043884992 @default.
• W2040933166 cites W2046844678 @default.
• W2040933166 cites W2047384740 @default.
• W2040933166 cites W2047710557 @default.
• W2040933166 cites W2048531806 @default.
• W2040933166 cites W2050088498 @default.
• W2040933166 cites W2050718942 @default.
• W2040933166 cites W2053094515 @default.
• W2040933166 cites W2053739443 @default.
• W2040933166 cites W2055151958 @default.
• W2040933166 cites W2056200351 @default.
• W2040933166 cites W2056878909 @default.
• W2040933166 cites W2057684612 @default.
• W2040933166 cites W2058718959 @default.
• W2040933166 cites W2059669521 @default.
• W2040933166 cites W2062012741 @default.
• W2040933166 cites W2064132586 @default.
• W2040933166 cites W2064623871 @default.
• W2040933166 cites W2064811874 @default.
• W2040933166 cites W2065488699 @default.
• W2040933166 cites W2066785847 @default.
• W2040933166 cites W2070137740 @default.
• W2040933166 cites W2071125722 @default.
• W2040933166 cites W2075278002 @default.
• W2040933166 cites W2075988072 @default.
• W2040933166 cites W2076425653 @default.
• W2040933166 cites W2076941160 @default.
• W2040933166 cites W2077508656 @default.

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