Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040941329> ?p ?o ?g. }
- W2040941329 endingPage "62" @default.
- W2040941329 startingPage "54" @default.
- W2040941329 abstract "Endotoxemia can lead to fluid metabolism alterations despite unchanged or elevated plasma vasopressin (VP) levels, suggesting a refractoriness of the kidney to the effect of the peptide. To test this hypothesis, we examined the effect of lipopolysaccharide (LPS) injection on the expression of V2 receptors and aquaporin-2 in the kidney.Plasma VP and urine osmolality, and binding of [3H]VP to kidney membranes, Western blot, and immunohistochemical analysis of aquaporin-2, in situ hybridization for V2 VP receptors and cytokines mRNAs were measured in the kidney 3 to 24 hours after LPS injection, 250 microg/100 g, intraperitoneally.LPS injection caused prolonged decreases in urine osmolality (up to 24 hours) without significant changes in plasma levels of sodium or VP. This was associated with marked decreases in V2 VP receptor mRNA and VP receptor number in the kidney, which were evident for up to 12 hours after LPS injection. Aquaporin-2 in kidney inner medulla was also reduced by about 50%. LPS induced interleukin (IL)-1beta in the kidney medulla by 3 hours, reached maximum at 6 hours, and started to decline by 12 hours, while it increased IL-6 mRNA significantly only at 3 hours. Interleukin mRNA expression was absent in kidneys of control rats. In vitro incubation of kidney medulla slices with IL-1beta reduced VP binding.The inflammatory response to acute endotoxemia down regulates V2 VP receptors and aquaporin-2 of the kidney inner medulla resulting in prolonged impairment of the renal capacity to concentrate urine." @default.
- W2040941329 created "2016-06-24" @default.
- W2040941329 creator A5010779419 @default.
- W2040941329 creator A5025600506 @default.
- W2040941329 creator A5027535624 @default.
- W2040941329 creator A5029048638 @default.
- W2040941329 creator A5063006329 @default.
- W2040941329 date "2004-01-01" @default.
- W2040941329 modified "2023-09-30" @default.
- W2040941329 title "Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla" @default.
- W2040941329 cites W1485026357 @default.
- W2040941329 cites W1900933807 @default.
- W2040941329 cites W1902184421 @default.
- W2040941329 cites W1969886388 @default.
- W2040941329 cites W1974517277 @default.
- W2040941329 cites W1994266582 @default.
- W2040941329 cites W1997535443 @default.
- W2040941329 cites W1997596092 @default.
- W2040941329 cites W1998699289 @default.
- W2040941329 cites W1999224438 @default.
- W2040941329 cites W2000241910 @default.
- W2040941329 cites W2003399747 @default.
- W2040941329 cites W2005104347 @default.
- W2040941329 cites W2006239660 @default.
- W2040941329 cites W2014629002 @default.
- W2040941329 cites W2018779154 @default.
- W2040941329 cites W2025171168 @default.
- W2040941329 cites W2036994812 @default.
- W2040941329 cites W2043757191 @default.
- W2040941329 cites W2043813981 @default.
- W2040941329 cites W2048796422 @default.
- W2040941329 cites W2067338751 @default.
- W2040941329 cites W2074297244 @default.
- W2040941329 cites W2078976057 @default.
- W2040941329 cites W2082414348 @default.
- W2040941329 cites W2090969152 @default.
- W2040941329 cites W2093407677 @default.
- W2040941329 cites W2110138744 @default.
- W2040941329 cites W2115433822 @default.
- W2040941329 cites W2123233116 @default.
- W2040941329 cites W2132452670 @default.
- W2040941329 cites W2133367977 @default.
- W2040941329 cites W2146342401 @default.
- W2040941329 cites W2148984043 @default.
- W2040941329 cites W2169097443 @default.
- W2040941329 cites W2408856947 @default.
- W2040941329 cites W2411937318 @default.
- W2040941329 doi "https://doi.org/10.1111/j.1523-1755.2004.00378.x" @default.
- W2040941329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14675036" @default.
- W2040941329 hasPublicationYear "2004" @default.
- W2040941329 type Work @default.
- W2040941329 sameAs 2040941329 @default.
- W2040941329 citedByCount "86" @default.
- W2040941329 countsByYear W20409413292012 @default.
- W2040941329 countsByYear W20409413292013 @default.
- W2040941329 countsByYear W20409413292014 @default.
- W2040941329 countsByYear W20409413292015 @default.
- W2040941329 countsByYear W20409413292016 @default.
- W2040941329 countsByYear W20409413292017 @default.
- W2040941329 countsByYear W20409413292018 @default.
- W2040941329 countsByYear W20409413292019 @default.
- W2040941329 countsByYear W20409413292020 @default.
- W2040941329 countsByYear W20409413292021 @default.
- W2040941329 countsByYear W20409413292022 @default.
- W2040941329 countsByYear W20409413292023 @default.
- W2040941329 crossrefType "journal-article" @default.
- W2040941329 hasAuthorship W2040941329A5010779419 @default.
- W2040941329 hasAuthorship W2040941329A5025600506 @default.
- W2040941329 hasAuthorship W2040941329A5027535624 @default.
- W2040941329 hasAuthorship W2040941329A5029048638 @default.
- W2040941329 hasAuthorship W2040941329A5063006329 @default.
- W2040941329 hasBestOaLocation W20409413291 @default.
- W2040941329 hasConcept C126322002 @default.
- W2040941329 hasConcept C127413603 @default.
- W2040941329 hasConcept C134018914 @default.
- W2040941329 hasConcept C170493617 @default.
- W2040941329 hasConcept C17291353 @default.
- W2040941329 hasConcept C185592680 @default.
- W2040941329 hasConcept C201289731 @default.
- W2040941329 hasConcept C20352681 @default.
- W2040941329 hasConcept C2775845273 @default.
- W2040941329 hasConcept C2776370428 @default.
- W2040941329 hasConcept C2776885963 @default.
- W2040941329 hasConcept C2778534349 @default.
- W2040941329 hasConcept C2778754761 @default.
- W2040941329 hasConcept C2780091579 @default.
- W2040941329 hasConcept C2780512574 @default.
- W2040941329 hasConcept C2780762869 @default.
- W2040941329 hasConcept C71924100 @default.
- W2040941329 hasConcept C78519656 @default.
- W2040941329 hasConcept C85562759 @default.
- W2040941329 hasConcept C86803240 @default.
- W2040941329 hasConcept C90474776 @default.
- W2040941329 hasConceptScore W2040941329C126322002 @default.
- W2040941329 hasConceptScore W2040941329C127413603 @default.
- W2040941329 hasConceptScore W2040941329C134018914 @default.
- W2040941329 hasConceptScore W2040941329C170493617 @default.
- W2040941329 hasConceptScore W2040941329C17291353 @default.