FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040956844> ?p ?o ?g. }

• W2040956844 endingPage "1765" @default.
• W2040956844 startingPage "1759" @default.
• W2040956844 abstract "Several studies have demonstrated beneficial effects of supplemental trivalent Cr in subjects with reduced insulin sensitivity with no documented signs of toxicity. However, recent studies have questioned the safety of supplemental trivalent Cr complexes. The objective of this study was to evaluate the cytotoxic and genotoxic potential of the Cr(III) complexes (histidinate, picolinate, and chloride) used as nutrient supplements compared with Cr(VI) dichromate. The cytotoxic and genotoxic effects of the Cr complexes were assessed in human HaCaT keratinocytes. The concentrations of Cr required to decrease cell viability were assessed by determining the ability of a keratinocyte cell line (HaCaT) to reduce tetrazolium dye, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. DNA damage using the Comet assay and the production of 8-hydroxy-2′-deoxyguanosine were also determined with and without hydrogen peroxide-induced stress. The LC50 for human cultured HaCaT keratinocytes was 50 μM for hexavalent sodium dichromate and more than 120-fold higher for Cr chloride (6 mM) and Cr histidinate (10 mM). For Cr picolinate at saturating concentration (120 μM) the LC50 was not attained. High Cr(III) concentrations, 250 μM Cr as Cr chloride and Cr histidinate and 120 μM Cr picolinate (highest amount soluble in the system), not only did not result in oxidative DNA damage but exhibited protective antioxidant effects when cells were exposed to hydrogen peroxide-induced oxidative stress. These data further support the low toxicity of trivalent Cr complexes used in nutrient supplements." @default.
• W2040956844 created "2016-06-24" @default.
• W2040956844 creator A5013233853 @default.
• W2040956844 creator A5021374777 @default.
• W2040956844 creator A5028516152 @default.
• W2040956844 creator A5044121715 @default.
• W2040956844 creator A5053254666 @default.
• W2040956844 creator A5081135601 @default.
• W2040956844 date "2007-06-15" @default.
• W2040956844 modified "2023-10-17" @default.
• W2040956844 title "Safety of trivalent chromium complexes: No evidence for DNA damage in human HaCaT keratinocytes" @default.
• W2040956844 cites W1487243507 @default.
• W2040956844 cites W1501063510 @default.
• W2040956844 cites W1510286602 @default.
• W2040956844 cites W1530262802 @default.
• W2040956844 cites W1653594454 @default.
• W2040956844 cites W1880042570 @default.
• W2040956844 cites W1967618549 @default.
• W2040956844 cites W1973574072 @default.
• W2040956844 cites W1978929205 @default.
• W2040956844 cites W1979854943 @default.
• W2040956844 cites W1986267238 @default.
• W2040956844 cites W1986909897 @default.
• W2040956844 cites W1994868809 @default.
• W2040956844 cites W1998004438 @default.
• W2040956844 cites W2000521155 @default.
• W2040956844 cites W2005189116 @default.
• W2040956844 cites W2007009509 @default.
• W2040956844 cites W2010609154 @default.
• W2040956844 cites W2013184222 @default.
• W2040956844 cites W2021306968 @default.
• W2040956844 cites W2030154800 @default.
• W2040956844 cites W2034759967 @default.
• W2040956844 cites W2047084762 @default.
• W2040956844 cites W2051087149 @default.
• W2040956844 cites W2054634712 @default.
• W2040956844 cites W2062229551 @default.
• W2040956844 cites W2067597129 @default.
• W2040956844 cites W2068118350 @default.
• W2040956844 cites W2073554915 @default.
• W2040956844 cites W2082383524 @default.
• W2040956844 cites W2083028740 @default.
• W2040956844 cites W2085204861 @default.
• W2040956844 cites W2085951179 @default.
• W2040956844 cites W2092629964 @default.
• W2040956844 cites W2093374393 @default.
• W2040956844 cites W2105905118 @default.
• W2040956844 cites W2121856272 @default.
• W2040956844 cites W2122663049 @default.
• W2040956844 cites W2123907427 @default.
• W2040956844 cites W2132322696 @default.
• W2040956844 cites W2140304913 @default.
• W2040956844 cites W2156828019 @default.
• W2040956844 cites W2158376461 @default.
• W2040956844 cites W2158829081 @default.
• W2040956844 cites W2166798220 @default.
• W2040956844 cites W2414737818 @default.
• W2040956844 cites W3044574244 @default.
• W2040956844 doi "https://doi.org/10.1016/j.freeradbiomed.2007.02.034" @default.
• W2040956844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17512455" @default.
• W2040956844 hasPublicationYear "2007" @default.
• W2040956844 type Work @default.
• W2040956844 sameAs 2040956844 @default.
• W2040956844 citedByCount "56" @default.
• W2040956844 countsByYear W20409568442012 @default.
• W2040956844 countsByYear W20409568442013 @default.
• W2040956844 countsByYear W20409568442014 @default.
• W2040956844 countsByYear W20409568442015 @default.
• W2040956844 countsByYear W20409568442016 @default.
• W2040956844 countsByYear W20409568442017 @default.
• W2040956844 countsByYear W20409568442018 @default.
• W2040956844 countsByYear W20409568442019 @default.
• W2040956844 countsByYear W20409568442021 @default.
• W2040956844 countsByYear W20409568442022 @default.
• W2040956844 crossrefType "journal-article" @default.
• W2040956844 hasAuthorship W2040956844A5013233853 @default.
• W2040956844 hasAuthorship W2040956844A5021374777 @default.
• W2040956844 hasAuthorship W2040956844A5028516152 @default.
• W2040956844 hasAuthorship W2040956844A5044121715 @default.
• W2040956844 hasAuthorship W2040956844A5053254666 @default.
• W2040956844 hasAuthorship W2040956844A5081135601 @default.
• W2040956844 hasConcept C118995209 @default.
• W2040956844 hasConcept C13965031 @default.
• W2040956844 hasConcept C143425029 @default.
• W2040956844 hasConcept C1491633281 @default.
• W2040956844 hasConcept C153911025 @default.
• W2040956844 hasConcept C178790620 @default.
• W2040956844 hasConcept C179104552 @default.
• W2040956844 hasConcept C185592680 @default.
• W2040956844 hasConcept C202751555 @default.
• W2040956844 hasConcept C2776151105 @default.
• W2040956844 hasConcept C2776300020 @default.
• W2040956844 hasConcept C2778004101 @default.
• W2040956844 hasConcept C2780358455 @default.
• W2040956844 hasConcept C2781468121 @default.
• W2040956844 hasConcept C29730261 @default.
• W2040956844 hasConcept C511782168 @default.
• W2040956844 hasConcept C53227056 @default.

• next