Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040962210> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2040962210 endingPage "743" @default.
- W2040962210 startingPage "738" @default.
- W2040962210 abstract "Summary As wound contraction can be prevented by full-thickness skin graft and enhanced by licking and since saliva contains growth-promoting macromolecules, we have studied the mechanical and humoral aspects of wound healing. Standardized burn and freeze-produced wounds were produced in rats. Contraction did not occur in wounds caused by freezing (n = 30), while burn wounds (n = 30) contracted to less than one-third of the original size in 3 weeks. If the centres of the freeze-produced wounds (n = 12) were excised, contraction would then occur and proceed at the same rate as open wounds (n = 12). The collagen contents of the burn wounds (n = 24) showed a greater initial loss followed by rapid replacement, while that of the freeze-produced wounds (n = 24) demonstrated a slower removal and more gradual replacement. Submandibular sialadenectomized mice (n = 34) and sham controls (n = 34) had excision of a standard sized patch of sacral skin. Through a separate abdominal incision polyvinyl sponges of known weight were introduced subcutaneously into all the animals. Mice without the submandibular salivary glands showed a slower rate of wound contraction than the sham controls (P<0.001). However, this delay in wound contraction was abolished if sialadenectomized mice were caged with mice having intact salivary glands. Collagen synthesis as determined by the hydroxyproline concentrations in the polyvinyl sponges were the same in both groups of animals irrespective of cage environment. Further standard sacral wounds in submandibular sialadenectomized mice (n = 120) were treated with different salivary components. Only high molecular weight nerve growth factor was able to accelerate wound contraction in these sialadenectomized animals to control values. In conclusion, the degree of wound contraction following injury is dependent on the integrity of the matrix, while the initiation of contraction is likely to be chemically induced." @default.
- W2040962210 created "2016-06-24" @default.
- W2040962210 creator A5014698753 @default.
- W2040962210 creator A5083500441 @default.
- W2040962210 date "1981-10-01" @default.
- W2040962210 modified "2023-10-14" @default.
- W2040962210 title "Mechanical and humoral factors in wound healing" @default.
- W2040962210 cites W1489992640 @default.
- W2040962210 cites W1894641937 @default.
- W2040962210 cites W1968189814 @default.
- W2040962210 cites W1969118439 @default.
- W2040962210 cites W1975262598 @default.
- W2040962210 cites W1978080363 @default.
- W2040962210 cites W1982425773 @default.
- W2040962210 cites W1987932065 @default.
- W2040962210 cites W1989748343 @default.
- W2040962210 cites W2009336694 @default.
- W2040962210 cites W2017865805 @default.
- W2040962210 cites W2018572253 @default.
- W2040962210 cites W2025420968 @default.
- W2040962210 cites W2027243420 @default.
- W2040962210 cites W2028666826 @default.
- W2040962210 cites W2029922699 @default.
- W2040962210 cites W2068162121 @default.
- W2040962210 cites W2082023003 @default.
- W2040962210 cites W2084168776 @default.
- W2040962210 cites W2092552905 @default.
- W2040962210 cites W2111704881 @default.
- W2040962210 cites W2164786826 @default.
- W2040962210 doi "https://doi.org/10.1002/bjs.1800681020" @default.
- W2040962210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7284738" @default.
- W2040962210 hasPublicationYear "1981" @default.
- W2040962210 type Work @default.
- W2040962210 sameAs 2040962210 @default.
- W2040962210 citedByCount "8" @default.
- W2040962210 countsByYear W20409622102012 @default.
- W2040962210 countsByYear W20409622102013 @default.
- W2040962210 crossrefType "journal-article" @default.
- W2040962210 hasAuthorship W2040962210A5014698753 @default.
- W2040962210 hasAuthorship W2040962210A5083500441 @default.
- W2040962210 hasConcept C126322002 @default.
- W2040962210 hasConcept C141071460 @default.
- W2040962210 hasConcept C163415756 @default.
- W2040962210 hasConcept C2779797417 @default.
- W2040962210 hasConcept C2780269544 @default.
- W2040962210 hasConcept C71924100 @default.
- W2040962210 hasConceptScore W2040962210C126322002 @default.
- W2040962210 hasConceptScore W2040962210C141071460 @default.
- W2040962210 hasConceptScore W2040962210C163415756 @default.
- W2040962210 hasConceptScore W2040962210C2779797417 @default.
- W2040962210 hasConceptScore W2040962210C2780269544 @default.
- W2040962210 hasConceptScore W2040962210C71924100 @default.
- W2040962210 hasFunder F4320322562 @default.
- W2040962210 hasIssue "10" @default.
- W2040962210 hasLocation W20409622101 @default.
- W2040962210 hasLocation W20409622102 @default.
- W2040962210 hasOpenAccess W2040962210 @default.
- W2040962210 hasPrimaryLocation W20409622101 @default.
- W2040962210 hasRelatedWork W1970708287 @default.
- W2040962210 hasRelatedWork W2002120878 @default.
- W2040962210 hasRelatedWork W2003938723 @default.
- W2040962210 hasRelatedWork W2047967234 @default.
- W2040962210 hasRelatedWork W2118496982 @default.
- W2040962210 hasRelatedWork W2352233024 @default.
- W2040962210 hasRelatedWork W2439875401 @default.
- W2040962210 hasRelatedWork W2892318211 @default.
- W2040962210 hasRelatedWork W4238867864 @default.
- W2040962210 hasRelatedWork W2525756941 @default.
- W2040962210 hasVolume "68" @default.
- W2040962210 isParatext "false" @default.
- W2040962210 isRetracted "false" @default.
- W2040962210 magId "2040962210" @default.
- W2040962210 workType "article" @default.