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• W2040963066 abstract "Thirty-two patients with hypernephroma (renal carcinoma), untreated or preoperatively exposed to local radiotherapy, were examined for tumor-directed cellular hypersensitivity by means of the indirect leukocyte migration test (LMΓ). (a) When soluble tumor extracts from preoperatively radiated hypernephromas were tested with autologous lymphocytes, 17 of 19 cancer patients gave a positive response; 10 of 11 were positive with allogeneic lymphocytes from hypernephroma patients. In no instance could migration inhibition be induced with allogeneic lymphocytes from 14 normal donors. Similarly, in 9 of 10 patients there was no significant inhibition with allogeneic lymphocytes from patients with histologically different types of malignant tumors other than hypernephroma. (b) Tissue extracts from untreated hypernephromas failed to react in 12 of 13 patients when tested with autologous lymphocytes. LMTs, however, became positive in 6 of 7 patients from this group by in vitro-radiation of tumor samples (60Co or electrons) before preparation of tissue extracts. This radiation-induced effect was dose-related and specific, since radiation of normal kidney tissue did not significantly influence the migratory activity of leukocytes. Our data indicating that an in vivo as well as in vitro-radiation of the hypernephroma will be suitable for the induction and the demonstration of a tumordirected cellular immune response, may be considered as an additional perspective in the integration of radiotherapy in the management of this neoplasia." @default.
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• W2040963066 date "1979-02-01" @default.
• W2040963066 modified "2023-09-27" @default.
• W2040963066 title "Studies on cellular immunity in patients with renal carcinoma: Radiation-induced inhibition of leukocyte migration" @default.
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• W2040963066 doi "https://doi.org/10.1016/0014-2964(79)90061-6" @default.
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