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- W2040966055 abstract "The synthesis of the 4-[11 C]methylamino derivative of N-{N-[4-(4-Aminophenyl)butyryl]-L-prolyl}pyrrolidine (SUAM-1221), is described as a potential marker for prolyl endopeptidase for in vivo positron emission tomography studies. Direct methylation of the 4-amino derivative of SUAM-1221 (1) with methyl iodide provided a mixture of the 4-monomethyl (2) and 4-dimethylamino (3) derivatives which were separated by chromatography. Methylation of 1 with [11 C]methyl iodide provided the 4-[11C]methylamino derivative of SUAM-1221, ([11C]2), in 18–30% decay corrected radiochemical yield after HPLC purification, with a specific activity > 1700 Ci/mmol and a 40 minute synthesis time from end of bombardment." @default.
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- W2040966055 date "1994-05-01" @default.
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- W2040966055 title "Synthesis of N-{N-[4-(4-{N-[11C]methylamino}phenyl)butyryl]-L-prolyl}pyrrolidine: A potential radiotracer for prolyl endopeptidase" @default.
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