Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040971945> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2040971945 endingPage "115" @default.
- W2040971945 startingPage "113" @default.
- W2040971945 abstract "Polyglutamate analogs of folate and related compounds were tested as inhibitors of casein kinase II (CK II) obtained from Xenopus laevis . The inhibitory capacity of the pteroyl, 4‐amino‐10‐methyl pteroyl (the methotrexate aromatic moiety), and p ‐aminobenzoil derivatives increased as the the number of γ‐glutamates attached went from 2 to 7. The nature of the aromatic head group was also important since hexa‐γ‐glutamatic acid had no inhibitory activity while the folylhexaglutamate derivatives were strong inhibitors with relative potency of methotrexate > pteroyl > p ‐aminobenzoic acid. The inhibition of CK II by methotrexate γ‐pentaglutamate was competitive with casein and showed an apparent K i of 90 μM." @default.
- W2040971945 created "2016-06-24" @default.
- W2040971945 creator A5023794388 @default.
- W2040971945 creator A5032017828 @default.
- W2040971945 creator A5068485825 @default.
- W2040971945 date "1992-08-17" @default.
- W2040971945 modified "2023-10-14" @default.
- W2040971945 title "Folylpolyglutamate analogs can inhibit casein kinase II from<i>Xenopus laevis</i>" @default.
- W2040971945 cites W1527291914 @default.
- W2040971945 cites W1556616823 @default.
- W2040971945 cites W1598727792 @default.
- W2040971945 cites W1666409248 @default.
- W2040971945 cites W1984772835 @default.
- W2040971945 cites W1997401774 @default.
- W2040971945 cites W2035842529 @default.
- W2040971945 cites W2038625034 @default.
- W2040971945 cites W2058471639 @default.
- W2040971945 cites W2067475721 @default.
- W2040971945 cites W2069112468 @default.
- W2040971945 cites W2071317316 @default.
- W2040971945 cites W2079524391 @default.
- W2040971945 cites W2084248231 @default.
- W2040971945 cites W2120261738 @default.
- W2040971945 cites W2124030177 @default.
- W2040971945 doi "https://doi.org/10.1016/0014-5793(92)81255-k" @default.
- W2040971945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1379942" @default.
- W2040971945 hasPublicationYear "1992" @default.
- W2040971945 type Work @default.
- W2040971945 sameAs 2040971945 @default.
- W2040971945 citedByCount "5" @default.
- W2040971945 countsByYear W20409719452015 @default.
- W2040971945 countsByYear W20409719452021 @default.
- W2040971945 crossrefType "journal-article" @default.
- W2040971945 hasAuthorship W2040971945A5023794388 @default.
- W2040971945 hasAuthorship W2040971945A5032017828 @default.
- W2040971945 hasAuthorship W2040971945A5068485825 @default.
- W2040971945 hasBestOaLocation W20409719451 @default.
- W2040971945 hasConcept C104317684 @default.
- W2040971945 hasConcept C185592680 @default.
- W2040971945 hasConcept C202751555 @default.
- W2040971945 hasConcept C2776142715 @default.
- W2040971945 hasConcept C2776568683 @default.
- W2040971945 hasConcept C2779535977 @default.
- W2040971945 hasConcept C55493867 @default.
- W2040971945 hasConcept C57992300 @default.
- W2040971945 hasConcept C71240020 @default.
- W2040971945 hasConceptScore W2040971945C104317684 @default.
- W2040971945 hasConceptScore W2040971945C185592680 @default.
- W2040971945 hasConceptScore W2040971945C202751555 @default.
- W2040971945 hasConceptScore W2040971945C2776142715 @default.
- W2040971945 hasConceptScore W2040971945C2776568683 @default.
- W2040971945 hasConceptScore W2040971945C2779535977 @default.
- W2040971945 hasConceptScore W2040971945C55493867 @default.
- W2040971945 hasConceptScore W2040971945C57992300 @default.
- W2040971945 hasConceptScore W2040971945C71240020 @default.
- W2040971945 hasIssue "2" @default.
- W2040971945 hasLocation W20409719451 @default.
- W2040971945 hasLocation W20409719452 @default.
- W2040971945 hasOpenAccess W2040971945 @default.
- W2040971945 hasPrimaryLocation W20409719451 @default.
- W2040971945 hasRelatedWork W1975075764 @default.
- W2040971945 hasRelatedWork W2045060966 @default.
- W2040971945 hasRelatedWork W2088374148 @default.
- W2040971945 hasRelatedWork W2141894622 @default.
- W2040971945 hasRelatedWork W2178558875 @default.
- W2040971945 hasRelatedWork W2949366517 @default.
- W2040971945 hasRelatedWork W2951269336 @default.
- W2040971945 hasRelatedWork W2951655361 @default.
- W2040971945 hasRelatedWork W2953317625 @default.
- W2040971945 hasRelatedWork W2023570923 @default.
- W2040971945 hasVolume "308" @default.
- W2040971945 isParatext "false" @default.
- W2040971945 isRetracted "false" @default.
- W2040971945 magId "2040971945" @default.
- W2040971945 workType "article" @default.