Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040974259> ?p ?o ?g. }
- W2040974259 endingPage "e1245" @default.
- W2040974259 startingPage "e1245" @default.
- W2040974259 abstract "Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a serious global health concern. Since their emergence in the mid-1970s multi-drug resistant (MDR) S. Typhi now dominate drug sensitive equivalents in many regions. MDR in S. Typhi is almost exclusively conferred by self-transmissible IncHI1 plasmids carrying a suite of antimicrobial resistance genes. We identified over 300 single nucleotide polymorphisms (SNPs) within conserved regions of the IncHI1 plasmid, and genotyped both plasmid and chromosomal SNPs in over 450 S. Typhi dating back to 1958. Prior to 1995, a variety of IncHI1 plasmid types were detected in distinct S. Typhi haplotypes. Highly similar plasmids were detected in co-circulating S. Typhi haplotypes, indicative of plasmid transfer. In contrast, from 1995 onwards, 98% of MDR S. Typhi were plasmid sequence type 6 (PST6) and S. Typhi haplotype H58, indicating recent global spread of a dominant MDR clone. To investigate whether PST6 conferred a selective advantage compared to other IncHI1 plasmids, we used a phenotyping array to compare the impact of IncHI1 PST6 and PST1 plasmids in a common S. Typhi host. The PST6 plasmid conferred the ability to grow in high salt medium (4.7% NaCl), which we demonstrate is due to the presence in PST6 of the Tn6062 transposon encoding BetU." @default.
- W2040974259 created "2016-06-24" @default.
- W2040974259 creator A5005131698 @default.
- W2040974259 creator A5007203736 @default.
- W2040974259 creator A5010264226 @default.
- W2040974259 creator A5028534327 @default.
- W2040974259 creator A5029035750 @default.
- W2040974259 creator A5032122956 @default.
- W2040974259 creator A5032691317 @default.
- W2040974259 creator A5046077459 @default.
- W2040974259 creator A5048713555 @default.
- W2040974259 creator A5072394609 @default.
- W2040974259 creator A5075382234 @default.
- W2040974259 creator A5075987933 @default.
- W2040974259 creator A5077121860 @default.
- W2040974259 creator A5080608098 @default.
- W2040974259 creator A5084268602 @default.
- W2040974259 creator A5091773898 @default.
- W2040974259 date "2011-07-19" @default.
- W2040974259 modified "2023-10-16" @default.
- W2040974259 title "Emergence of a Globally Dominant IncHI1 Plasmid Type Associated with Multiple Drug Resistant Typhoid" @default.
- W2040974259 cites W1484319464 @default.
- W2040974259 cites W1706101476 @default.
- W2040974259 cites W1824289027 @default.
- W2040974259 cites W1843904177 @default.
- W2040974259 cites W1931518744 @default.
- W2040974259 cites W1965882073 @default.
- W2040974259 cites W1967229113 @default.
- W2040974259 cites W1973045856 @default.
- W2040974259 cites W1984852783 @default.
- W2040974259 cites W1994697944 @default.
- W2040974259 cites W1997064353 @default.
- W2040974259 cites W2001628607 @default.
- W2040974259 cites W2003342030 @default.
- W2040974259 cites W2011355767 @default.
- W2040974259 cites W2025900548 @default.
- W2040974259 cites W2036994733 @default.
- W2040974259 cites W2045751247 @default.
- W2040974259 cites W2051727227 @default.
- W2040974259 cites W2054839242 @default.
- W2040974259 cites W2056140363 @default.
- W2040974259 cites W2056432511 @default.
- W2040974259 cites W2065479587 @default.
- W2040974259 cites W2071936366 @default.
- W2040974259 cites W2080528409 @default.
- W2040974259 cites W2081153548 @default.
- W2040974259 cites W2084231307 @default.
- W2040974259 cites W2090649262 @default.
- W2040974259 cites W2094939159 @default.
- W2040974259 cites W2097448744 @default.
- W2040974259 cites W2103872524 @default.
- W2040974259 cites W2106446204 @default.
- W2040974259 cites W2107282968 @default.
- W2040974259 cites W2110309880 @default.
- W2040974259 cites W2110397906 @default.
- W2040974259 cites W2110835349 @default.
- W2040974259 cites W2112113834 @default.
- W2040974259 cites W2117752525 @default.
- W2040974259 cites W2119004823 @default.
- W2040974259 cites W2125429181 @default.
- W2040974259 cites W2127232702 @default.
- W2040974259 cites W2127372292 @default.
- W2040974259 cites W2127860918 @default.
- W2040974259 cites W2129452342 @default.
- W2040974259 cites W2135146244 @default.
- W2040974259 cites W2137565578 @default.
- W2040974259 cites W2144233138 @default.
- W2040974259 cites W2146648724 @default.
- W2040974259 cites W2147278081 @default.
- W2040974259 cites W2147541630 @default.
- W2040974259 cites W2150828940 @default.
- W2040974259 cites W2151118386 @default.
- W2040974259 cites W2152423233 @default.
- W2040974259 cites W2153432740 @default.
- W2040974259 cites W2155705049 @default.
- W2040974259 cites W2166708001 @default.
- W2040974259 cites W2167891320 @default.
- W2040974259 cites W2168213072 @default.
- W2040974259 cites W2171624472 @default.
- W2040974259 cites W2313231986 @default.
- W2040974259 doi "https://doi.org/10.1371/journal.pntd.0001245" @default.
- W2040974259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3139670" @default.
- W2040974259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21811646" @default.
- W2040974259 hasPublicationYear "2011" @default.
- W2040974259 type Work @default.
- W2040974259 sameAs 2040974259 @default.
- W2040974259 citedByCount "111" @default.
- W2040974259 countsByYear W20409742592012 @default.
- W2040974259 countsByYear W20409742592013 @default.
- W2040974259 countsByYear W20409742592014 @default.
- W2040974259 countsByYear W20409742592015 @default.
- W2040974259 countsByYear W20409742592016 @default.
- W2040974259 countsByYear W20409742592017 @default.
- W2040974259 countsByYear W20409742592018 @default.
- W2040974259 countsByYear W20409742592019 @default.
- W2040974259 countsByYear W20409742592020 @default.
- W2040974259 countsByYear W20409742592021 @default.
- W2040974259 countsByYear W20409742592022 @default.