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• W2040974763 abstract "A new series of indole amide acting as hCRTH2 receptor ligands had been explored and are described herein. Several amide derivatives displaying low nanomolar activity in hCRTH2 binding and whole blood assays were identified. They were found to behave as a full antagonists, exhibiting good selectivity over related prostaglandin receptors. Also, prototypical compounds in this novel series which displayed acceptable CYP profiles and were orally bioavailable in rats were identified." @default.
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• W2040974763 date "2011-06-01" @default.
• W2040974763 modified "2023-10-01" @default.
• W2040974763 title "New indole amide derivatives as potent CRTH2 receptor antagonists" @default.
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• W2040974763 doi "https://doi.org/10.1016/j.bmcl.2011.03.085" @default.
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