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- W2040981306 endingPage "194" @default.
- W2040981306 startingPage "181" @default.
- W2040981306 abstract "The study of haemoglobin switching has represented a focus in haematology due in large part to the clinical relevance of the fetal to adult haemoglobin switch for developing targeted approaches to ameliorate the severity of the β-haemoglobinopathies. Additionally, the process by which this switch occurs represents an important paradigm for developmental gene regulation. In this review, we provide an overview of both the embryonic primitive to definitive switch in haemoglobin expression, as well as the fetal to adult switch that is unique to humans and old world monkeys. We discuss the nature of these switches and models of their regulation. The factors that have been suggested to regulate this process are then discussed. With the increased understanding and discovery of molecular regulators of haemoglobin switching, such as BCL11A, new avenues of research may lead ultimately to novel therapeutic, mechanism-based approaches to fetal haemoglobin reactivation in patients." @default.
- W2040981306 created "2016-06-24" @default.
- W2040981306 creator A5003021419 @default.
- W2040981306 creator A5029222284 @default.
- W2040981306 creator A5088119941 @default.
- W2040981306 date "2010-04-01" @default.
- W2040981306 modified "2023-09-30" @default.
- W2040981306 title "Advances in the understanding of haemoglobin switching" @default.
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