FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040983864> ?p ?o ?g. }

• W2040983864 abstract "In spite of advances in psychotherapy and pharmacotherapy, there are still a significant number of patients with depression and obsessive-compulsive disorder that are not aided by either intervention. Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders. The purpose of this study is to systematically review reports on clinical trials of DBS for obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). Locations for stimulation, success rates and effects of the stimulation on brain metabolism are noted when available. The first observation of the effects of DBS on OCD and TRD came in the course of using DBS to treat movement disorders. Reports of changes in OCD and depression during such studies are reviewed with particular attention to electrode locations and associated adverse events; although these reports were adventitious observations rather than planned. Subsequent studies have been guided by more precise theories of structures involved in DBS and OICD. This study suggests stimulation sites and prognostic indicators for DBS. We also briefly review tractography, a relatively new procedure that holds great promise for the further development of DBS. Articles were retrieved from MEDLINE via PubMed. Relevant references in retrieved articles were followed up. We included all articles reporting on studies of patients selected for having OCD or TRD. Adequacy of the selected studies was evaluated by the Jadad scale. Evaluation criteria included: number of patients, use of recognized psychiatric rating scales, and use of brain blood flow measurements. Success rates classified as improved or recovered were recorded. Studies of DBS for movement disorders were included if they reported coincidental relief of depression or reduction in OCD. Most of the studies involved small numbers of subjects so individual studies were reviewed. While the number of cases was small, these were extremely treatment-resistant patients. While not everyone responded, about half the patients did show dramatic improvement. Associated adverse events were generally trivial in younger psychiatric patients but often severe in older movement disorder patients. The procedures differed from study to study, and the numbers of patients was usually too small to do meaningful statistics or make valid inferences as to who will respond to treatment. DBS is considered a promising technique for OCD and TRD. Outstanding questions about patient selection and electrode placement can probably be resolved by (a) larger studies, (b) genetic studies and (c) imaging studies (MRI, fMRI, PET, and tractography)." @default.
• W2040983864 created "2016-06-24" @default.
• W2040983864 creator A5027008374 @default.
• W2040983864 creator A5079941092 @default.
• W2040983864 date "2010-03-04" @default.
• W2040983864 modified "2023-10-14" @default.
• W2040983864 title "Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review" @default.
• W2040983864 cites W148042706 @default.
• W2040983864 cites W1480729244 @default.
• W2040983864 cites W149201658 @default.
• W2040983864 cites W1822152264 @default.
• W2040983864 cites W1941457575 @default.
• W2040983864 cites W1974816318 @default.
• W2040983864 cites W1975222549 @default.
• W2040983864 cites W1986215651 @default.
• W2040983864 cites W1987054111 @default.
• W2040983864 cites W1989029973 @default.
• W2040983864 cites W1989466565 @default.
• W2040983864 cites W1993492541 @default.
• W2040983864 cites W1996063129 @default.
• W2040983864 cites W2004529637 @default.
• W2040983864 cites W2006621603 @default.
• W2040983864 cites W2007049689 @default.
• W2040983864 cites W2012635324 @default.
• W2040983864 cites W2014786844 @default.
• W2040983864 cites W2021492964 @default.
• W2040983864 cites W2021782736 @default.
• W2040983864 cites W2026342961 @default.
• W2040983864 cites W2032715840 @default.
• W2040983864 cites W2033561476 @default.
• W2040983864 cites W2038693293 @default.
• W2040983864 cites W2046213396 @default.
• W2040983864 cites W2053126345 @default.
• W2040983864 cites W2066340608 @default.
• W2040983864 cites W2070319582 @default.
• W2040983864 cites W2071648788 @default.
• W2040983864 cites W2073718251 @default.
• W2040983864 cites W2093638798 @default.
• W2040983864 cites W2100991928 @default.
• W2040983864 cites W2108805521 @default.
• W2040983864 cites W2111456519 @default.
• W2040983864 cites W2114114862 @default.
• W2040983864 cites W2116228807 @default.
• W2040983864 cites W2121278129 @default.
• W2040983864 cites W2121648229 @default.
• W2040983864 cites W2128274387 @default.
• W2040983864 cites W2132969335 @default.
• W2040983864 cites W2156495551 @default.
• W2040983864 cites W2161118302 @default.
• W2040983864 cites W2419635271 @default.
• W2040983864 cites W2777987555 @default.
• W2040983864 cites W4244189582 @default.
• W2040983864 cites W55327208 @default.
• W2040983864 doi "https://doi.org/10.1186/1756-0500-3-60" @default.
• W2040983864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2838907" @default.
• W2040983864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20202203" @default.
• W2040983864 hasPublicationYear "2010" @default.
• W2040983864 type Work @default.
• W2040983864 sameAs 2040983864 @default.
• W2040983864 citedByCount "64" @default.
• W2040983864 countsByYear W20409838642012 @default.
• W2040983864 countsByYear W20409838642013 @default.
• W2040983864 countsByYear W20409838642014 @default.
• W2040983864 countsByYear W20409838642015 @default.
• W2040983864 countsByYear W20409838642016 @default.
• W2040983864 countsByYear W20409838642017 @default.
• W2040983864 countsByYear W20409838642018 @default.
• W2040983864 countsByYear W20409838642019 @default.
• W2040983864 countsByYear W20409838642020 @default.
• W2040983864 countsByYear W20409838642021 @default.
• W2040983864 countsByYear W20409838642022 @default.
• W2040983864 countsByYear W20409838642023 @default.
• W2040983864 crossrefType "journal-article" @default.
• W2040983864 hasAuthorship W2040983864A5027008374 @default.
• W2040983864 hasAuthorship W2040983864A5079941092 @default.
• W2040983864 hasBestOaLocation W20409838641 @default.
• W2040983864 hasConcept C118552586 @default.
• W2040983864 hasConcept C126322002 @default.
• W2040983864 hasConcept C136524200 @default.
• W2040983864 hasConcept C138496976 @default.
• W2040983864 hasConcept C139719470 @default.
• W2040983864 hasConcept C15744967 @default.
• W2040983864 hasConcept C162324750 @default.
• W2040983864 hasConcept C168563851 @default.
• W2040983864 hasConcept C169900460 @default.
• W2040983864 hasConcept C17744445 @default.
• W2040983864 hasConcept C197934379 @default.
• W2040983864 hasConcept C199539241 @default.
• W2040983864 hasConcept C24998067 @default.
• W2040983864 hasConcept C2776478404 @default.
• W2040983864 hasConcept C2776867660 @default.
• W2040983864 hasConcept C2777342061 @default.
• W2040983864 hasConcept C2778542668 @default.
• W2040983864 hasConcept C2779134260 @default.
• W2040983864 hasConcept C2779473830 @default.
• W2040983864 hasConcept C2779734285 @default.
• W2040983864 hasConcept C2780051608 @default.
• W2040983864 hasConcept C2985799443 @default.
• W2040983864 hasConcept C71924100 @default.
• W2040983864 hasConcept C83849319 @default.

• next