FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040984959> ?p ?o ?g. }

• W2040984959 endingPage "1517" @default.
• W2040984959 startingPage "1510" @default.
• W2040984959 abstract "In this study, we assessed the role of melanocortin 1 receptor (MC1R) variants and of two patched (PTCH) polymorphisms (c.3944C>T (P1315L), insertion 18 bp IVS1-83) as risk factors for basal cell carcinoma (BCC) in the French population. The population investigated comprised 126 BCC patients who were enrolled on the basis of specific criteria (multiple and/or familial BCC and/or onset before the age of 40 years and/or association with another tumor)--and 151 controls matched for ethnicity, age, and sex. MC1R variants appeared as a moderate risk factor for BCC (odds ratio (OR) for one and two variants, 2.17 [1.28-3.68] and 7.72 [3.42-17.38], respectively), independently of pigmentation characteristics (OR = 2.53 [1.34-4.8]). Interestingly, in addition to the predictable red hair color (RHC) alleles, two non-RHC alleles (V60L and V92M) were also closely associated with BCC risk (OR 3.21 [1.91-5.38] and 2.87 [1.5-5.48], respectively), which differs from the situation in the Celtic population. In addition, the PTCH c.3944C/C genotype was also associated with BCC risk (OR 1.94 [1.2-3.1]), especially in the subgroup of patients with multiple tumors (OR 2.16 [1.3-3.6]). Thus, our data show that MC1R and PTCH variants are associated with BCC risk in the French population. We further suggest that assessing MC1R and PTCH status could be useful, combined with the assessment of clinical risk factors, in identifying high-risk patients to be targeted for prevention or more rigorous surveillance." @default.
• W2040984959 created "2016-06-24" @default.
• W2040984959 creator A5025478490 @default.
• W2040984959 creator A5033499830 @default.
• W2040984959 creator A5034402801 @default.
• W2040984959 creator A5037376216 @default.
• W2040984959 creator A5042447894 @default.
• W2040984959 creator A5058773961 @default.
• W2040984959 creator A5059190410 @default.
• W2040984959 creator A5059444495 @default.
• W2040984959 creator A5061869243 @default.
• W2040984959 creator A5065244911 @default.
• W2040984959 creator A5070552593 @default.
• W2040984959 creator A5074214434 @default.
• W2040984959 creator A5088572311 @default.
• W2040984959 date "2006-07-01" @default.
• W2040984959 modified "2023-10-17" @default.
• W2040984959 title "MC1R and PTCH Gene Polymorphism in French Patients with Basal Cell Carcinomas" @default.
• W2040984959 cites W1552282019 @default.
• W2040984959 cites W1568830230 @default.
• W2040984959 cites W1964961771 @default.
• W2040984959 cites W1973947033 @default.
• W2040984959 cites W1979580952 @default.
• W2040984959 cites W1991633189 @default.
• W2040984959 cites W2001670469 @default.
• W2040984959 cites W2004210300 @default.
• W2040984959 cites W2007740682 @default.
• W2040984959 cites W2010462296 @default.
• W2040984959 cites W2028130288 @default.
• W2040984959 cites W2039479644 @default.
• W2040984959 cites W2047903112 @default.
• W2040984959 cites W2055356976 @default.
• W2040984959 cites W2055523163 @default.
• W2040984959 cites W2070332388 @default.
• W2040984959 cites W2074065112 @default.
• W2040984959 cites W2080357302 @default.
• W2040984959 cites W2101121350 @default.
• W2040984959 cites W2102158228 @default.
• W2040984959 cites W2102889133 @default.
• W2040984959 cites W2115022580 @default.
• W2040984959 cites W2118094114 @default.
• W2040984959 cites W2123639353 @default.
• W2040984959 cites W2124085000 @default.
• W2040984959 cites W2127001212 @default.
• W2040984959 cites W2128391918 @default.
• W2040984959 cites W2133235730 @default.
• W2040984959 cites W2133821784 @default.
• W2040984959 cites W2137370771 @default.
• W2040984959 cites W2143688478 @default.
• W2040984959 cites W2148840288 @default.
• W2040984959 cites W4250928742 @default.
• W2040984959 cites W4252865728 @default.
• W2040984959 doi "https://doi.org/10.1038/sj.jid.5700263" @default.
• W2040984959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16645598" @default.
• W2040984959 hasPublicationYear "2006" @default.
• W2040984959 type Work @default.
• W2040984959 sameAs 2040984959 @default.
• W2040984959 citedByCount "71" @default.
• W2040984959 countsByYear W20409849592012 @default.
• W2040984959 countsByYear W20409849592013 @default.
• W2040984959 countsByYear W20409849592014 @default.
• W2040984959 countsByYear W20409849592015 @default.
• W2040984959 countsByYear W20409849592016 @default.
• W2040984959 countsByYear W20409849592017 @default.
• W2040984959 countsByYear W20409849592018 @default.
• W2040984959 countsByYear W20409849592020 @default.
• W2040984959 countsByYear W20409849592021 @default.
• W2040984959 countsByYear W20409849592022 @default.
• W2040984959 countsByYear W20409849592023 @default.
• W2040984959 crossrefType "journal-article" @default.
• W2040984959 hasAuthorship W2040984959A5025478490 @default.
• W2040984959 hasAuthorship W2040984959A5033499830 @default.
• W2040984959 hasAuthorship W2040984959A5034402801 @default.
• W2040984959 hasAuthorship W2040984959A5037376216 @default.
• W2040984959 hasAuthorship W2040984959A5042447894 @default.
• W2040984959 hasAuthorship W2040984959A5058773961 @default.
• W2040984959 hasAuthorship W2040984959A5059190410 @default.
• W2040984959 hasAuthorship W2040984959A5059444495 @default.
• W2040984959 hasAuthorship W2040984959A5061869243 @default.
• W2040984959 hasAuthorship W2040984959A5065244911 @default.
• W2040984959 hasAuthorship W2040984959A5070552593 @default.
• W2040984959 hasAuthorship W2040984959A5074214434 @default.
• W2040984959 hasAuthorship W2040984959A5088572311 @default.
• W2040984959 hasBestOaLocation W20409849591 @default.
• W2040984959 hasConcept C104317684 @default.
• W2040984959 hasConcept C126322002 @default.
• W2040984959 hasConcept C135763542 @default.
• W2040984959 hasConcept C143998085 @default.
• W2040984959 hasConcept C156957248 @default.
• W2040984959 hasConcept C180754005 @default.
• W2040984959 hasConcept C182843373 @default.
• W2040984959 hasConcept C2777994357 @default.
• W2040984959 hasConcept C2778539099 @default.
• W2040984959 hasConcept C2778804307 @default.
• W2040984959 hasConcept C2908647359 @default.
• W2040984959 hasConcept C3019992690 @default.
• W2040984959 hasConcept C50440223 @default.
• W2040984959 hasConcept C54355233 @default.

• next