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• W2040985191 abstract "The transcription factor NF-κB is critical for T-cell activation and survival. We have shown that mice expressing a T-cell-restricted NF-κB superrepressor (IκBαΔN-Tg) permanently accept heart but not skin allografts. Overexpression of the prosurvival factor Bcl-xL in T cells restored heart rejection, suggesting that graft acceptance in IκBαΔN-Tg mice was attributable to deletion of alloreactive T cells.In vitro, the increased death of IκBαΔN-Tg T cells upon TCR stimulation when compared with wildtype T cells was mostly because of Fas/FasL interaction. Similarly, Fas played a key role in cardiac allograft acceptance by IκBαΔN-Tg mice as both genetic and antibody-mediated inhibition of Fas-signaling restored cardiac allograft rejection. Rejection correlated with graft infiltration by T cells and splenic production of IFN-γ upon allostimulation. These results indicate that T-cell inhibition of NF-κB results in cardiac allograft acceptance because of increased susceptibility to Fas-mediated cell death." @default.
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• W2040985191 date "2009-08-01" @default.
• W2040985191 modified "2023-10-16" @default.
• W2040985191 title "Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-κB signaling" @default.
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• W2040985191 doi "https://doi.org/10.1111/j.1432-2277.2009.00875.x" @default.
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