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- W2040987769 abstract "Here we analysed the involvement of tyrosine phosphorylation in the regulation of the initial molecular events induced by IL-13 to modulate TPA-triggered reactive oxygen intermediates (ROI) production. Our data indicate that treatment of monocytes with a protein tyrosine kinase inhibitor (herbimycin A) prevents IL-13-induced cAMP accumulation and subsequent ROI inhibition. We have previously demonstrated that cAMP accumulation dependes on inositol phosphates hydrolysis (InsPs) and intracellular Ca2+mobilisation. The inhibition of InsPsand intracellular Ca2+release by herbimycin A suggests a primary role of tyrosine kinases upstream PLC activation. We further specify that IL-13 stimulates PLC-γ1 and IRS-2 tyrosine phosphorylation in human monocytes. We demonstrate for the first time that IL-13 induces the association of IRS-2 with PLC-γ1. We proposed here that PLC-γ1 is a new candidate recruited by IRS-2." @default.
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- W2040987769 date "1998-03-01" @default.
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- W2040987769 title "IL-13 Induces Tyrosine Phosphorylation of Phospholipase Cγ-1 Following IRS-2 Association in Human Monocytes: Relationship with the Inhibitory Effect of IL-13 on ROI Production" @default.
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- W2040987769 doi "https://doi.org/10.1006/bbrc.1998.8314" @default.
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