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• W2040989089 abstract "<b>Background: </b> Currently, there are no published randomized controlled trials evaluating the efficacy and safety of adjunctive antiepileptic therapy in idiopathic generalized epilepsy with myoclonic seizures. <b>Methods: </b> This randomized, double-blind, placebo-controlled multicenter trial assessed the efficacy and tolerability of adjunctive treatment with levetiracetam 3,000 mg/day in adolescents (≥12 years) and adults (≤65 years) with idiopathic generalized epilepsy, who experienced myoclonic seizures on ≥8 days during a prospective 8-week baseline period, despite antiepileptic monotherapy. The 8-week baseline period was followed by 4-week up-titration, 12-week evaluation, and 6-week down-titration/conversion periods. <b>Results: </b> Of 122 patients randomized, 120 (levetiracetam, n = 60; placebo, n = 60) were evaluable. Diagnoses were either juvenile myoclonic epilepsy (93.4%) or juvenile absence epilepsy (6.6%). A reduction of ≥50% in the number of days/week with myoclonic seizures was seen in 58.3% of patients in the levetiracetam group and in 23.3% of patients in the placebo group (<i>p</i> < 0.001) during the treatment period. Levetiracetam-treated patients were more likely to respond to treatment than patients receiving placebo (OR = 4.77; 95% CI, 2.12 to 10.77; <i>p</i> < 0.001). Levetiracetam-treated patients had higher freedom from myoclonic seizures (25.0% vs 5.0%; <i>p</i> = 0.004) and all seizure types (21.7% vs 1.7%; <i>p</i> < 0.001) during the evaluation period. The only adverse events more frequent with levetiracetam were somnolence and neck pain. <b>Conclusion: </b> These results suggest that levetiracetam is an effective and well-tolerated adjunctive treatment for patients with previously uncontrolled idiopathic generalized epilepsy with myoclonic seizures." @default.
• W2040989089 created "2016-06-24" @default.
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• W2040989089 date "2008-02-19" @default.
• W2040989089 modified "2023-09-26" @default.
• W2040989089 title "Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures" @default.
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• W2040989089 doi "https://doi.org/10.1212/01.wnl.0000297512.18364.40" @default.
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