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- W2040989917 abstract "To the Editor.— Healing of osseous metastases is usually described as a recalcification process and is best seen in osteolytic lesions. 1 Osteoblastic lesions are more difficult to evaluate. Eighty percent of the skeletal metastases in prostatic carcinoma are purely osteoblastic in nature 2 ; thus, the evaluation of improvement is difficult. Endocrine therapy may bring about a dramatic clinical improvement associated with return of acid and alkaline phosphatase values to normal, but the roentgenographic appearance of the blastic lesions rarely changes. In an early report, Huggins and co-workers 3 claimed that all patients with prostatic carcinoma who underwent orchiectomy had increased osteosclerosis of the skeletal metastases. Others 2 have reported an occasional shrinkage of osteoblastic lesions, but complete disappearance of osteoblastic metastases has never, to our knowledge, been previously reported. Two patients treated with estramustine phosphate (Estracyt) who were observed for more than three years exhibited a gradual complete disappearance" @default.
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- W2040989917 date "1977-06-06" @default.
- W2040989917 modified "2023-09-23" @default.
- W2040989917 title "Disappearance of Osteoblastic Metastases in Prostatic Carcinoma Following Estramustine Therapy" @default.
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- W2040989917 doi "https://doi.org/10.1001/jama.1977.03270500023011" @default.
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