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- W2040990844 abstract "The effects of yohimbine, rauwolscine and corynanthine on clonidine-induced depression of exploration (ambulation and rearing) in the rat were investigate. Yohimbine and rauwolscine antagonized clonidine-induced hypoactivity in a dose-range of 0.3−3 mg/kg i.p. By contrast, corynanthine was found to lack such an effect up to ten times higher doses. These results are in agreement with the reported differential affinity of these drugs for the α 2 -and α 1 adrenoceptors respectively and suggest the involvement of α 2 -receptor in the mediation of depressant effect of clonidine. The antagonism of clonidine-induced hypoactivity appears, therefore, to provide a suitable in vivo measure of preferential α 2 -adrenoceptor blocking of drugs." @default.
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- W2040990844 date "1982-02-01" @default.
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- W2040990844 title "Effects of yohimbine and its diastereoisomers on clonidine-induced depression of exploration in the rat" @default.
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- W2040990844 doi "https://doi.org/10.1016/0014-2999(82)90139-x" @default.
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