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- W2040993149 abstract "The role of pulsatile flow as a physiologic stimulus for endothelium mediated vasoregulation is poorly understood. Furthermore, non pulsatile flow, which is associated with increased vascular resistance and end-organ failure, has been demonstrated to lead to a decrease in nitric oxide (NO) production in vitro. Anesthetized pigs (23.4 ± 0.3 kg) were placed on cardiopulmonary bypass using either non pulsatile or pulsatile perfusion for 60 min. In both groups, animals were maintained with a constant mean aortic flow (1.0–1.3 L/min). Serum samples obtained during bypass were assayed for the stable end-products of NO (nitrate [NO3-] and nitrite [NO2-]) by a method based on the Greiss reaction. Systemic vascular resistance was higher after 60 min in the non pulsatile (3712.5 ± 481.2 dyne sec cm-5) vs the pulsatile group (2672.6 ± 427.0 dyne sec cm-5), but not statistically significant (p > .05). However, NO production was decreased in the non pulsatile flow group (27 ± 6%) vs the pulsatile flow group (14 ± 5%) at a statistically significant level (p < .005). The results suggest that non pulsatile flow is associated with diminished endothelial shear stress and a reduction in endothelial nitric oxide production. This may contribute to the detrimental physiologic effects observed in prolonged non pulsatile flow states." @default.
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- W2040993149 date "1996-09-01" @default.
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- W2040993149 title "The Vasoregulatory Role of Endothelium Derived Nitric Oxide During Pulsatile Cardiopulmonary Bypass" @default.
- W2040993149 doi "https://doi.org/10.1097/00002480-199609000-00101" @default.
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