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• W2040993603 startingPage "405" @default.
• W2040993603 abstract "The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers an intracellular signaling pathway, the unfolded protein response (UPR), that leads to increased transcription of genes encoding ER-resident proteins. Transcriptional activation is mediated by a dedicated transcription factor, Hac1p, whose activity is controlled by regulated splicing of its mRNA. We have identified a mutation in tRNA ligase that disrupts the UPR in the yeast Saccharomyces cerevisiae. In this mutant, splicing of HAC1 mRNA, but not tRNA, is blocked. In contrast, HAC1 mRNA splicing is not impaired in cells that are blocked in spliceosome-mediated mRNA splicing. Furthermore, the splice junctions of HAC1 mRNA do not conform to the consensus sequences of other yeast pre-mRNAs. Our results suggest that the regulated splicing of HAC1 mRNA occurs by a novel pathway, involving tRNA ligase and bypassing the spliceosome." @default.
• W2040993603 created "2016-06-24" @default.
• W2040993603 creator A5002738943 @default.
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• W2040993603 date "1996-11-01" @default.
• W2040993603 modified "2023-10-12" @default.
• W2040993603 title "tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response" @default.
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• W2040993603 doi "https://doi.org/10.1016/s0092-8674(00)81361-6" @default.
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