FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040997618> ?p ?o ?g. }

• W2040997618 endingPage "96" @default.
• W2040997618 startingPage "87" @default.
• W2040997618 abstract "Chronic mechanical stress of the heart secondary to arterial hypertension is a primary cause of left ventricular hypertrophy (LVH). The renin-angiotensin system (RAS) plays an important role in the cardiovascular system, regulating the expression of cardiac hypertrophy, in part, independent of the effects of systemic hypertension. A major component of RAS is angiotensin converting enzyme (ACE), which is upregulated in pressure overload-induced cardiac hypertrophy as well as heart failure. In a recent study, we found that the T allele of the M235T polymorphism of the angiotensinogen gene in sporadic hypertrophic cardiomyopathy (HCM) patients is associated with LVH. The present study was designed to assess the contribution of the polymorphisms of the angiotensin II type 1 receptor (AGT1R A1166C) genes on development of left ventricular hypertrophy. Patients with hypertensive LVH and relatives of HCM without manifesting the disease, showed higher C allele frequency compared to patients with HCM (11.3% vs 4.2%, χ2=5.3, p<0.05 and 10.5% vs 4.2%, χ2=5.3, p<0.05, respectively), but healthy controls did not (11.3% vs 7.5%, χ2=1.42, NS and 10.5% vs 7.5%, χ2=1.2, NS).The strong interaction between ACE I/D and AGT1R A1166C gene polymorphisms has been found in groups of relatives of HCM patients; odds ratio associated with ACE D allele was significant in subjects carrying the AGT1R C allele (OR=7.3, 95% CI 1.6-33.1; χ2=7.9, p<0.02) compared with healthy subjects.We conclude that the molecular variant of the AGT1R A1166C gene is not contributing to the development of cardiac hypertrophy in hypertensive LVH and HCM patients, whereas carriers of both C and D alleles had a four-fold increase in the odds ratio for family history of HCM without manifesting the disease." @default.
• W2040997618 created "2016-06-24" @default.
• W2040997618 creator A5001188770 @default.
• W2040997618 creator A5005074641 @default.
• W2040997618 creator A5027959389 @default.
• W2040997618 creator A5034534753 @default.
• W2040997618 creator A5035723767 @default.
• W2040997618 creator A5053914726 @default.
• W2040997618 creator A5059316181 @default.
• W2040997618 creator A5066924600 @default.
• W2040997618 creator A5076492463 @default.
• W2040997618 creator A5083221298 @default.
• W2040997618 date "1998-01-01" @default.
• W2040997618 modified "2023-10-02" @default.
• W2040997618 title "Angiotensin II Type 1 Receptor Gene Polymorphisms in Patients with Cardiac Hypertrophy." @default.
• W2040997618 cites W1990888036 @default.
• W2040997618 cites W1993123294 @default.
• W2040997618 cites W2010031713 @default.
• W2040997618 cites W2014049741 @default.
• W2040997618 cites W2018240474 @default.
• W2040997618 cites W2044728287 @default.
• W2040997618 cites W2058680526 @default.
• W2040997618 cites W2090146136 @default.
• W2040997618 cites W2119114835 @default.
• W2040997618 cites W2129772911 @default.
• W2040997618 cites W2130501592 @default.
• W2040997618 cites W2142393775 @default.
• W2040997618 cites W2144057484 @default.
• W2040997618 cites W2151458434 @default.
• W2040997618 cites W2158455070 @default.
• W2040997618 cites W2314183680 @default.
• W2040997618 doi "https://doi.org/10.1536/ihj.39.87" @default.
• W2040997618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9601485" @default.
• W2040997618 hasPublicationYear "1998" @default.
• W2040997618 type Work @default.
• W2040997618 sameAs 2040997618 @default.
• W2040997618 citedByCount "13" @default.
• W2040997618 countsByYear W20409976182017 @default.
• W2040997618 crossrefType "journal-article" @default.
• W2040997618 hasAuthorship W2040997618A5001188770 @default.
• W2040997618 hasAuthorship W2040997618A5005074641 @default.
• W2040997618 hasAuthorship W2040997618A5027959389 @default.
• W2040997618 hasAuthorship W2040997618A5034534753 @default.
• W2040997618 hasAuthorship W2040997618A5035723767 @default.
• W2040997618 hasAuthorship W2040997618A5053914726 @default.
• W2040997618 hasAuthorship W2040997618A5059316181 @default.
• W2040997618 hasAuthorship W2040997618A5066924600 @default.
• W2040997618 hasAuthorship W2040997618A5076492463 @default.
• W2040997618 hasAuthorship W2040997618A5083221298 @default.
• W2040997618 hasBestOaLocation W20409976181 @default.
• W2040997618 hasConcept C104317684 @default.
• W2040997618 hasConcept C126322002 @default.
• W2040997618 hasConcept C134018914 @default.
• W2040997618 hasConcept C164705383 @default.
• W2040997618 hasConcept C167414201 @default.
• W2040997618 hasConcept C180754005 @default.
• W2040997618 hasConcept C198710026 @default.
• W2040997618 hasConcept C2776002628 @default.
• W2040997618 hasConcept C2778198053 @default.
• W2040997618 hasConcept C2778797674 @default.
• W2040997618 hasConcept C2780045698 @default.
• W2040997618 hasConcept C2780185194 @default.
• W2040997618 hasConcept C2908929049 @default.
• W2040997618 hasConcept C54355233 @default.
• W2040997618 hasConcept C71924100 @default.
• W2040997618 hasConcept C84393581 @default.
• W2040997618 hasConcept C86803240 @default.
• W2040997618 hasConceptScore W2040997618C104317684 @default.
• W2040997618 hasConceptScore W2040997618C126322002 @default.
• W2040997618 hasConceptScore W2040997618C134018914 @default.
• W2040997618 hasConceptScore W2040997618C164705383 @default.
• W2040997618 hasConceptScore W2040997618C167414201 @default.
• W2040997618 hasConceptScore W2040997618C180754005 @default.
• W2040997618 hasConceptScore W2040997618C198710026 @default.
• W2040997618 hasConceptScore W2040997618C2776002628 @default.
• W2040997618 hasConceptScore W2040997618C2778198053 @default.
• W2040997618 hasConceptScore W2040997618C2778797674 @default.
• W2040997618 hasConceptScore W2040997618C2780045698 @default.
• W2040997618 hasConceptScore W2040997618C2780185194 @default.
• W2040997618 hasConceptScore W2040997618C2908929049 @default.
• W2040997618 hasConceptScore W2040997618C54355233 @default.
• W2040997618 hasConceptScore W2040997618C71924100 @default.
• W2040997618 hasConceptScore W2040997618C84393581 @default.
• W2040997618 hasConceptScore W2040997618C86803240 @default.
• W2040997618 hasIssue "1" @default.
• W2040997618 hasLocation W20409976181 @default.
• W2040997618 hasLocation W20409976182 @default.
• W2040997618 hasOpenAccess W2040997618 @default.
• W2040997618 hasPrimaryLocation W20409976181 @default.
• W2040997618 hasRelatedWork W2016647631 @default.
• W2040997618 hasRelatedWork W2025107008 @default.
• W2040997618 hasRelatedWork W2037200837 @default.
• W2040997618 hasRelatedWork W2042660006 @default.
• W2040997618 hasRelatedWork W2091058874 @default.
• W2040997618 hasRelatedWork W2125138303 @default.
• W2040997618 hasRelatedWork W2126797993 @default.
• W2040997618 hasRelatedWork W2149272589 @default.
• W2040997618 hasRelatedWork W2408890477 @default.

• next