Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040998738> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2040998738 endingPage "149" @default.
- W2040998738 startingPage "143" @default.
- W2040998738 abstract "The role of endogenous regucalcin (RC) in the regulation of cell proliferation was investigated in the cloned rat hepatoma H4-II-E cells overexpressing RC stably. H4-II-E cells were transfected with RC/pCXN2 vector and the multiple neomycin-resistant clones which overexpress stably RC were selected. The RC content of RC/pCXN2-transfected cells used in this study was 19.7-fold as compared with that of the parental wild type H4-II-E cells. Wild type H4-II-E cells, pCXN2 vector-transfected cells (mock type), and RC/pCXN2-transfected cells (transfectants) were cultured for 24, 48, and 72 h in the presence of fetal bovine serum (10% FBS). Cell numbers of wild and mock type were significantly increased with the time course of culture. Cell numbers of transfectants was significantly suppressed as compared with that of wild and mock type. Deoxyribonucleic acid (DNA) synthesis activity in the nuclear fraction of H4-II-E cells was significantly suppressed in transfectants with culture for 12–48 h. The presence of anti-RC monoclonal antibody (10–50 ng/ml) in the reaction mixture caused a significant increase in DNA synthesis activity in the nuclei of wild type and transfectants; this increase was remarkable in transfectants. The effect of anti-RC monoclonal antibody (50 ng/ml) in increasing DNA synthesis activity in transfectants was completely prevented by the addition of regucalcin (1 μM). This study demonstrates that cell proliferation is suppressed in the cloned rat hepatoma H4-II-E overexpressing RC stably. J. Cell. Biochem. 84: 143–149, 2002. © 2001 Wiley-Liss, Inc." @default.
- W2040998738 created "2016-06-24" @default.
- W2040998738 creator A5004062198 @default.
- W2040998738 creator A5075607809 @default.
- W2040998738 creator A5087546500 @default.
- W2040998738 date "2001-11-02" @default.
- W2040998738 modified "2023-09-25" @default.
- W2040998738 title "Suppression of cell proliferation and deoxyribonucleic acid synthesis in the cloned rat hepatoma H4-II-E cells overexpressing regucalcin" @default.
- W2040998738 cites W1484536008 @default.
- W2040998738 cites W1775749144 @default.
- W2040998738 cites W195406790 @default.
- W2040998738 cites W1964504843 @default.
- W2040998738 cites W1964839077 @default.
- W2040998738 cites W1971926903 @default.
- W2040998738 cites W1989470354 @default.
- W2040998738 cites W1996801850 @default.
- W2040998738 cites W1997286248 @default.
- W2040998738 cites W2002675461 @default.
- W2040998738 cites W2004107544 @default.
- W2040998738 cites W2010424836 @default.
- W2040998738 cites W2011224377 @default.
- W2040998738 cites W2040390163 @default.
- W2040998738 cites W2040953750 @default.
- W2040998738 cites W2043451831 @default.
- W2040998738 cites W2048162805 @default.
- W2040998738 cites W2054914725 @default.
- W2040998738 cites W2056342811 @default.
- W2040998738 cites W2096365708 @default.
- W2040998738 cites W2100547386 @default.
- W2040998738 cites W2136453191 @default.
- W2040998738 cites W2260123734 @default.
- W2040998738 cites W2313423833 @default.
- W2040998738 cites W2323920430 @default.
- W2040998738 cites W237874500 @default.
- W2040998738 doi "https://doi.org/10.1002/jcb.1274" @default.
- W2040998738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746523" @default.
- W2040998738 hasPublicationYear "2001" @default.
- W2040998738 type Work @default.
- W2040998738 sameAs 2040998738 @default.
- W2040998738 citedByCount "74" @default.
- W2040998738 countsByYear W20409987382012 @default.
- W2040998738 countsByYear W20409987382013 @default.
- W2040998738 countsByYear W20409987382014 @default.
- W2040998738 countsByYear W20409987382015 @default.
- W2040998738 countsByYear W20409987382016 @default.
- W2040998738 countsByYear W20409987382017 @default.
- W2040998738 countsByYear W20409987382018 @default.
- W2040998738 countsByYear W20409987382019 @default.
- W2040998738 countsByYear W20409987382020 @default.
- W2040998738 countsByYear W20409987382021 @default.
- W2040998738 countsByYear W20409987382022 @default.
- W2040998738 countsByYear W20409987382023 @default.
- W2040998738 crossrefType "journal-article" @default.
- W2040998738 hasAuthorship W2040998738A5004062198 @default.
- W2040998738 hasAuthorship W2040998738A5075607809 @default.
- W2040998738 hasAuthorship W2040998738A5087546500 @default.
- W2040998738 hasConcept C153911025 @default.
- W2040998738 hasConcept C185592680 @default.
- W2040998738 hasConcept C2779404806 @default.
- W2040998738 hasConcept C54009773 @default.
- W2040998738 hasConcept C54355233 @default.
- W2040998738 hasConcept C552990157 @default.
- W2040998738 hasConcept C55493867 @default.
- W2040998738 hasConcept C62112901 @default.
- W2040998738 hasConcept C64241487 @default.
- W2040998738 hasConcept C81885089 @default.
- W2040998738 hasConcept C86803240 @default.
- W2040998738 hasConceptScore W2040998738C153911025 @default.
- W2040998738 hasConceptScore W2040998738C185592680 @default.
- W2040998738 hasConceptScore W2040998738C2779404806 @default.
- W2040998738 hasConceptScore W2040998738C54009773 @default.
- W2040998738 hasConceptScore W2040998738C54355233 @default.
- W2040998738 hasConceptScore W2040998738C552990157 @default.
- W2040998738 hasConceptScore W2040998738C55493867 @default.
- W2040998738 hasConceptScore W2040998738C62112901 @default.
- W2040998738 hasConceptScore W2040998738C64241487 @default.
- W2040998738 hasConceptScore W2040998738C81885089 @default.
- W2040998738 hasConceptScore W2040998738C86803240 @default.
- W2040998738 hasIssue "1" @default.
- W2040998738 hasLocation W20409987381 @default.
- W2040998738 hasLocation W20409987382 @default.
- W2040998738 hasOpenAccess W2040998738 @default.
- W2040998738 hasPrimaryLocation W20409987381 @default.
- W2040998738 hasRelatedWork W2040998738 @default.
- W2040998738 hasRelatedWork W2053393868 @default.
- W2040998738 hasRelatedWork W2057925004 @default.
- W2040998738 hasRelatedWork W2163799657 @default.
- W2040998738 hasRelatedWork W2347120132 @default.
- W2040998738 hasRelatedWork W2351812146 @default.
- W2040998738 hasRelatedWork W2371993946 @default.
- W2040998738 hasRelatedWork W2379152510 @default.
- W2040998738 hasRelatedWork W2384261171 @default.
- W2040998738 hasRelatedWork W2462877824 @default.
- W2040998738 hasVolume "84" @default.
- W2040998738 isParatext "false" @default.
- W2040998738 isRetracted "false" @default.
- W2040998738 magId "2040998738" @default.
- W2040998738 workType "article" @default.