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- W2040999906 abstract "A report on the development of a model for the computer-guided administration of sufentanil throughout surgical procedures involving cardiopulmonary-bypass (CB) is presented. The authors approach the effects of hypothermia on sufentanil clearance by applying a continuous temperature correction to the ultimate elimination rate constant (the terminal eigenvalue). This correction is based primarily on the anticipated effects of temperature on the enzyme-catalyzed reactions which are essential for the elimination of the drug from the body. An algorithm for the application of the model is also presented.< <ETX xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>></ETX>" @default.
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- W2040999906 title "Development of a real-time algorithm for predicting sufentanil plasma levels during cardiopulmonary-bypass surgery, using a systems approach" @default.
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