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- W2041001058 abstract "Significance The enzymes required for the incorporation of host fatty acids into the membrane phospholipids of Gram-positive bacterial pathogens are unknown. Fatty acid kinase (Fak) is a new enzyme in lipid metabolism that requires two proteins to form acyl-phosphate: an ATP binding-domain protein (FakA) that interacts with a fatty acid binding protein (FakB). The analysis of Staphylococcus aureus mutants reveals that Fak is essential for phospholipid synthesis from extracellular fatty acids and also impacts the transcription of numerous virulence factors. This study reveals the function for two large bacterial protein families and their essential role in host fatty acid metabolism by pathogens, and connects Fak to the regulation of virulence factor transcription in S. aureus ." @default.
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- W2041001058 date "2014-07-07" @default.
- W2041001058 modified "2023-10-02" @default.
- W2041001058 title "Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by <i>Staphylococcus aureus</i>" @default.
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- W2041001058 doi "https://doi.org/10.1073/pnas.1408797111" @default.
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