Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041014352> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2041014352 endingPage "405" @default.
- W2041014352 startingPage "401" @default.
- W2041014352 abstract "Objective: The limited availability of donor sites for nerve grafts and the morbidity associated with their harvesting serve as motivating factors to actively conduct research to find alternatives to the status quo. Experimental and clinical studies have shown that a vein segment used to bridge a peripheral nerve defect leads to a functional nerve repair. Both FK-506 and b-FGF have been reported to enhance peripheral nerve regeneration. This study compared the effects of FK-506 with that of b-FGF on peripheral nerve regeneration in a rat autogenous vein graft conduit model. Methods: The main trunk of the right sciatic nerve was transected and bridged by an autogenous vein in 30 rats. Small osmotic pumps were placed just proximal to the anastomoses. Groups of 10 rats were assigned to receive saline solution, b-FGF (2,000 units), or FK-506 (0.5 mg/kg/day) via the osmotic pumps for 2 weeks. Sciatic nerve regeneration was evaluated by sensory function, walking track analysis, electrophysiologic studies, and light microscopic evaluation. Results: On post-operative day 90, there was a statistically significant difference (p <.005) in nerve regeneration between the rats who received saline compared with those who received FK-506 or b-FGF. This was determined using sensory function tests, sciatic function index, and electrophysiologic studies. The number of nerve axons, as determined by histological analysis, revealed there were significantly more nerve fibers which were regenerated in both experimental groups (FK-506 and b-FGF) when compared with rats who received saline. There was no statistically significant difference in the number of nerve axons that regenerated in rats injected with FK-506 vs. rats injected with b-FGF. Conclusion: FK-506 and b-FGF promote similar nerve regeneration in rats compared with control." @default.
- W2041014352 created "2016-06-24" @default.
- W2041014352 creator A5016182229 @default.
- W2041014352 creator A5034417823 @default.
- W2041014352 creator A5040721503 @default.
- W2041014352 creator A5050900142 @default.
- W2041014352 date "2009-12-15" @default.
- W2041014352 modified "2023-10-14" @default.
- W2041014352 title "Comparing FK-506 with Basic Fibroblast Growth Factor (b-FGF) on the Repair of a Peripheral Nerve Defect Using an Autogenous Vein Bridge Model" @default.
- W2041014352 cites W1999853485 @default.
- W2041014352 cites W2014260239 @default.
- W2041014352 cites W2026840150 @default.
- W2041014352 cites W2033234296 @default.
- W2041014352 cites W2045306649 @default.
- W2041014352 cites W2054113611 @default.
- W2041014352 cites W2078099913 @default.
- W2041014352 cites W2080713302 @default.
- W2041014352 cites W2111096871 @default.
- W2041014352 cites W2149650439 @default.
- W2041014352 cites W234690121 @default.
- W2041014352 cites W2411930161 @default.
- W2041014352 cites W2419411847 @default.
- W2041014352 cites W3140373293 @default.
- W2041014352 cites W4323966328 @default.
- W2041014352 doi "https://doi.org/10.3109/08941930903410775" @default.
- W2041014352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20001808" @default.
- W2041014352 hasPublicationYear "2009" @default.
- W2041014352 type Work @default.
- W2041014352 sameAs 2041014352 @default.
- W2041014352 citedByCount "10" @default.
- W2041014352 countsByYear W20410143522012 @default.
- W2041014352 countsByYear W20410143522013 @default.
- W2041014352 countsByYear W20410143522015 @default.
- W2041014352 countsByYear W20410143522017 @default.
- W2041014352 countsByYear W20410143522019 @default.
- W2041014352 countsByYear W20410143522020 @default.
- W2041014352 crossrefType "journal-article" @default.
- W2041014352 hasAuthorship W2041014352A5016182229 @default.
- W2041014352 hasAuthorship W2041014352A5034417823 @default.
- W2041014352 hasAuthorship W2041014352A5040721503 @default.
- W2041014352 hasAuthorship W2041014352A5050900142 @default.
- W2041014352 hasConcept C105702510 @default.
- W2041014352 hasConcept C126322002 @default.
- W2041014352 hasConcept C141071460 @default.
- W2041014352 hasConcept C170493617 @default.
- W2041014352 hasConcept C171056886 @default.
- W2041014352 hasConcept C2776880756 @default.
- W2041014352 hasConcept C2777202286 @default.
- W2041014352 hasConcept C2777397205 @default.
- W2041014352 hasConcept C2779530196 @default.
- W2041014352 hasConcept C2781149210 @default.
- W2041014352 hasConcept C3018498973 @default.
- W2041014352 hasConcept C42219234 @default.
- W2041014352 hasConcept C46762472 @default.
- W2041014352 hasConcept C71924100 @default.
- W2041014352 hasConcept C74373430 @default.
- W2041014352 hasConcept C8443397 @default.
- W2041014352 hasConcept C86803240 @default.
- W2041014352 hasConcept C95444343 @default.
- W2041014352 hasConceptScore W2041014352C105702510 @default.
- W2041014352 hasConceptScore W2041014352C126322002 @default.
- W2041014352 hasConceptScore W2041014352C141071460 @default.
- W2041014352 hasConceptScore W2041014352C170493617 @default.
- W2041014352 hasConceptScore W2041014352C171056886 @default.
- W2041014352 hasConceptScore W2041014352C2776880756 @default.
- W2041014352 hasConceptScore W2041014352C2777202286 @default.
- W2041014352 hasConceptScore W2041014352C2777397205 @default.
- W2041014352 hasConceptScore W2041014352C2779530196 @default.
- W2041014352 hasConceptScore W2041014352C2781149210 @default.
- W2041014352 hasConceptScore W2041014352C3018498973 @default.
- W2041014352 hasConceptScore W2041014352C42219234 @default.
- W2041014352 hasConceptScore W2041014352C46762472 @default.
- W2041014352 hasConceptScore W2041014352C71924100 @default.
- W2041014352 hasConceptScore W2041014352C74373430 @default.
- W2041014352 hasConceptScore W2041014352C8443397 @default.
- W2041014352 hasConceptScore W2041014352C86803240 @default.
- W2041014352 hasConceptScore W2041014352C95444343 @default.
- W2041014352 hasIssue "6" @default.
- W2041014352 hasLocation W20410143521 @default.
- W2041014352 hasLocation W20410143522 @default.
- W2041014352 hasOpenAccess W2041014352 @default.
- W2041014352 hasPrimaryLocation W20410143521 @default.
- W2041014352 hasRelatedWork W2008492572 @default.
- W2041014352 hasRelatedWork W2029478548 @default.
- W2041014352 hasRelatedWork W2048435747 @default.
- W2041014352 hasRelatedWork W2381401425 @default.
- W2041014352 hasRelatedWork W2413479133 @default.
- W2041014352 hasRelatedWork W2947465422 @default.
- W2041014352 hasRelatedWork W3014779327 @default.
- W2041014352 hasRelatedWork W3027967615 @default.
- W2041014352 hasRelatedWork W4220861295 @default.
- W2041014352 hasRelatedWork W4290357574 @default.
- W2041014352 hasVolume "22" @default.
- W2041014352 isParatext "false" @default.
- W2041014352 isRetracted "false" @default.
- W2041014352 magId "2041014352" @default.
- W2041014352 workType "article" @default.