Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041042880> ?p ?o ?g. }
- W2041042880 endingPage "42" @default.
- W2041042880 startingPage "36" @default.
- W2041042880 abstract "Mesenteric lymph pathway serves as the primary route by which gut injury leads to systemic inflammation and distant organ injury. The inflammation of the intestinal tract is partially mediated by vasoactive intestinal peptide (VIP). Therefore, the aim of this study was to test whether exogenous VIP affects mesenteric lymph pathway during early intestinal ischemia-reperfusion (IIR) injury. Rats were randomized into control, control+VIP, IIR and IIR+VIP groups. The observation of mesenteric lymph flow was carried out by cannulation of mesenteric lymphatics. The distribution of in vivo lymphocyte trafficking was performed by (51)Cr labeled lymphocytes and was measured by γ-counter. Endotoxin concentration was assayed using the limulus test kit and TNF-α level was detected by ELISA. When IIR injury treated with VIP, the volumes of lymph flow increased by 80%, which caused the number of lymphocytes exiting in mesenteric lymphatic increased by 50% while the proportion of (51)Cr-lymphocytes in Peyer's patches, intestinal effector tissues, mesenteric nodes, large intestine, stomach decreased by 58%, 51%, 58%, 63%, 64% respectively at the 6th h after reperfusion following intestinal ischemia. Meanwhile, endotoxin and TNF-α levels in intestinal lymph decreased by 51% and 83%. These results suggest that exogenous VIP ameliorates IIR induced splanchnic organ damage via inhibition of toxic mediators reaching systemic circulation and reinforcement of the effective immune responses in gut-associated lymphoid tissues (GALT)." @default.
- W2041042880 created "2016-06-24" @default.
- W2041042880 creator A5002267808 @default.
- W2041042880 creator A5005206049 @default.
- W2041042880 creator A5056744141 @default.
- W2041042880 creator A5067430613 @default.
- W2041042880 date "2013-09-01" @default.
- W2041042880 modified "2023-09-25" @default.
- W2041042880 title "Effects of exogenous vasoactive intestinal peptide on mesenteric lymph pathway during early intestinal ischemia–reperfusion injury in rats" @default.
- W2041042880 cites W1488560084 @default.
- W2041042880 cites W1636391291 @default.
- W2041042880 cites W1964065006 @default.
- W2041042880 cites W1964760958 @default.
- W2041042880 cites W1966464365 @default.
- W2041042880 cites W1974962876 @default.
- W2041042880 cites W1984396187 @default.
- W2041042880 cites W1995084062 @default.
- W2041042880 cites W1998004700 @default.
- W2041042880 cites W1998493815 @default.
- W2041042880 cites W2001682169 @default.
- W2041042880 cites W2008574893 @default.
- W2041042880 cites W2023343969 @default.
- W2041042880 cites W2023988302 @default.
- W2041042880 cites W2028898179 @default.
- W2041042880 cites W2032497440 @default.
- W2041042880 cites W2033457017 @default.
- W2041042880 cites W2033964070 @default.
- W2041042880 cites W2056707198 @default.
- W2041042880 cites W2060860593 @default.
- W2041042880 cites W2063661991 @default.
- W2041042880 cites W2070636175 @default.
- W2041042880 cites W2075591728 @default.
- W2041042880 cites W2082669179 @default.
- W2041042880 cites W2097585375 @default.
- W2041042880 cites W2121191646 @default.
- W2041042880 cites W2122025387 @default.
- W2041042880 cites W2125078538 @default.
- W2041042880 cites W2160894539 @default.
- W2041042880 cites W2162142579 @default.
- W2041042880 cites W2409917698 @default.
- W2041042880 cites W4254004012 @default.
- W2041042880 cites W4313341493 @default.
- W2041042880 doi "https://doi.org/10.1016/j.regpep.2013.06.014" @default.
- W2041042880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23872373" @default.
- W2041042880 hasPublicationYear "2013" @default.
- W2041042880 type Work @default.
- W2041042880 sameAs 2041042880 @default.
- W2041042880 citedByCount "2" @default.
- W2041042880 countsByYear W20410428802014 @default.
- W2041042880 countsByYear W20410428802022 @default.
- W2041042880 crossrefType "journal-article" @default.
- W2041042880 hasAuthorship W2041042880A5002267808 @default.
- W2041042880 hasAuthorship W2041042880A5005206049 @default.
- W2041042880 hasAuthorship W2041042880A5056744141 @default.
- W2041042880 hasAuthorship W2041042880A5067430613 @default.
- W2041042880 hasBestOaLocation W20410428801 @default.
- W2041042880 hasConcept C118303440 @default.
- W2041042880 hasConcept C126322002 @default.
- W2041042880 hasConcept C134018914 @default.
- W2041042880 hasConcept C142724271 @default.
- W2041042880 hasConcept C158846371 @default.
- W2041042880 hasConcept C170493617 @default.
- W2041042880 hasConcept C181152851 @default.
- W2041042880 hasConcept C203014093 @default.
- W2041042880 hasConcept C2775849017 @default.
- W2041042880 hasConcept C2779237934 @default.
- W2041042880 hasConcept C2779720271 @default.
- W2041042880 hasConcept C2780114680 @default.
- W2041042880 hasConcept C3019368612 @default.
- W2041042880 hasConcept C541997718 @default.
- W2041042880 hasConcept C71924100 @default.
- W2041042880 hasConcept C8330315 @default.
- W2041042880 hasConcept C8891405 @default.
- W2041042880 hasConceptScore W2041042880C118303440 @default.
- W2041042880 hasConceptScore W2041042880C126322002 @default.
- W2041042880 hasConceptScore W2041042880C134018914 @default.
- W2041042880 hasConceptScore W2041042880C142724271 @default.
- W2041042880 hasConceptScore W2041042880C158846371 @default.
- W2041042880 hasConceptScore W2041042880C170493617 @default.
- W2041042880 hasConceptScore W2041042880C181152851 @default.
- W2041042880 hasConceptScore W2041042880C203014093 @default.
- W2041042880 hasConceptScore W2041042880C2775849017 @default.
- W2041042880 hasConceptScore W2041042880C2779237934 @default.
- W2041042880 hasConceptScore W2041042880C2779720271 @default.
- W2041042880 hasConceptScore W2041042880C2780114680 @default.
- W2041042880 hasConceptScore W2041042880C3019368612 @default.
- W2041042880 hasConceptScore W2041042880C541997718 @default.
- W2041042880 hasConceptScore W2041042880C71924100 @default.
- W2041042880 hasConceptScore W2041042880C8330315 @default.
- W2041042880 hasConceptScore W2041042880C8891405 @default.
- W2041042880 hasLocation W20410428801 @default.
- W2041042880 hasLocation W20410428802 @default.
- W2041042880 hasOpenAccess W2041042880 @default.
- W2041042880 hasPrimaryLocation W20410428801 @default.
- W2041042880 hasRelatedWork W1483474920 @default.
- W2041042880 hasRelatedWork W1978730674 @default.
- W2041042880 hasRelatedWork W2041042880 @default.
- W2041042880 hasRelatedWork W2146275744 @default.