Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041047289> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2041047289 endingPage "83" @default.
- W2041047289 startingPage "78" @default.
- W2041047289 abstract "The structure of the gene encoding ZN-16, a transcription factor that binds to the mammalian growth hormone promoter in tandem with Pit-1, was determined in order to elucidate the exon–intron organization of the 16 zinc finger domains of the protein. Southern hybridization of mouse genomic DNA showed fragments with sizes identical to those predicted from mouse ZN-16 cDNA for two different probes covering the 2200 aa coding frame. Mouse genome database sequences also showed no introns in the zn-16 coding regions on chromosome 4. Analysis of human zn-16 by Southern hybridization and genomic database sequence analysis also indicated a single exon for the human protein coding sequences. BLASTP query of available genomic databases with critical zinc finger residues from mouse ZN-16 identified highly similar canine, bovine, and chimpanzee genomic sequences that encode proteins. Phylogenetic analysis of these mammalian proteins resulted in relationships as would be expected in species spanning rodents to humans. All six independent zn-16 sequences show a single exon coding region with no introns, a similarity ruling out the possibility that these genomic sequences are pseudogenes. Thus, mammalian zn-16 has a compact single exon structure encoding a very large protein (2200–3000 aa), the conservation of which may have functional implications such as the importance of posttranscriptional modifications." @default.
- W2041047289 created "2016-06-24" @default.
- W2041047289 creator A5037833467 @default.
- W2041047289 creator A5063574016 @default.
- W2041047289 date "2006-03-01" @default.
- W2041047289 modified "2023-09-23" @default.
- W2041047289 title "Growth hormone transcription factor ZN-16 genomic coding regions are composed of a single exon and are evolutionarily conserved in mammals" @default.
- W2041047289 cites W1970132032 @default.
- W2041047289 cites W1974131176 @default.
- W2041047289 cites W1974531581 @default.
- W2041047289 cites W1980751345 @default.
- W2041047289 cites W2013122665 @default.
- W2041047289 cites W2020234751 @default.
- W2041047289 cites W2036643569 @default.
- W2041047289 cites W2050953312 @default.
- W2041047289 cites W2051731919 @default.
- W2041047289 cites W2052698568 @default.
- W2041047289 cites W2054570685 @default.
- W2041047289 cites W2062617470 @default.
- W2041047289 cites W2065462808 @default.
- W2041047289 cites W2077024995 @default.
- W2041047289 cites W2091995782 @default.
- W2041047289 cites W2121071095 @default.
- W2041047289 cites W2152554255 @default.
- W2041047289 cites W2167989032 @default.
- W2041047289 cites W4229829601 @default.
- W2041047289 cites W4234811877 @default.
- W2041047289 cites W4240466903 @default.
- W2041047289 cites W4246765409 @default.
- W2041047289 doi "https://doi.org/10.1016/j.gene.2005.10.010" @default.
- W2041047289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16303260" @default.
- W2041047289 hasPublicationYear "2006" @default.
- W2041047289 type Work @default.
- W2041047289 sameAs 2041047289 @default.
- W2041047289 citedByCount "3" @default.
- W2041047289 countsByYear W20410472892016 @default.
- W2041047289 countsByYear W20410472892017 @default.
- W2041047289 countsByYear W20410472892020 @default.
- W2041047289 crossrefType "journal-article" @default.
- W2041047289 hasAuthorship W2041047289A5037833467 @default.
- W2041047289 hasAuthorship W2041047289A5063574016 @default.
- W2041047289 hasConcept C101762097 @default.
- W2041047289 hasConcept C104317684 @default.
- W2041047289 hasConcept C141231307 @default.
- W2041047289 hasConcept C150194340 @default.
- W2041047289 hasConcept C156446351 @default.
- W2041047289 hasConcept C167625842 @default.
- W2041047289 hasConcept C17757408 @default.
- W2041047289 hasConcept C187882448 @default.
- W2041047289 hasConcept C199216141 @default.
- W2041047289 hasConcept C22322919 @default.
- W2041047289 hasConcept C24284526 @default.
- W2041047289 hasConcept C34957205 @default.
- W2041047289 hasConcept C36823959 @default.
- W2041047289 hasConcept C54355233 @default.
- W2041047289 hasConcept C86339819 @default.
- W2041047289 hasConcept C86803240 @default.
- W2041047289 hasConcept C91779695 @default.
- W2041047289 hasConcept C94671646 @default.
- W2041047289 hasConceptScore W2041047289C101762097 @default.
- W2041047289 hasConceptScore W2041047289C104317684 @default.
- W2041047289 hasConceptScore W2041047289C141231307 @default.
- W2041047289 hasConceptScore W2041047289C150194340 @default.
- W2041047289 hasConceptScore W2041047289C156446351 @default.
- W2041047289 hasConceptScore W2041047289C167625842 @default.
- W2041047289 hasConceptScore W2041047289C17757408 @default.
- W2041047289 hasConceptScore W2041047289C187882448 @default.
- W2041047289 hasConceptScore W2041047289C199216141 @default.
- W2041047289 hasConceptScore W2041047289C22322919 @default.
- W2041047289 hasConceptScore W2041047289C24284526 @default.
- W2041047289 hasConceptScore W2041047289C34957205 @default.
- W2041047289 hasConceptScore W2041047289C36823959 @default.
- W2041047289 hasConceptScore W2041047289C54355233 @default.
- W2041047289 hasConceptScore W2041047289C86339819 @default.
- W2041047289 hasConceptScore W2041047289C86803240 @default.
- W2041047289 hasConceptScore W2041047289C91779695 @default.
- W2041047289 hasConceptScore W2041047289C94671646 @default.
- W2041047289 hasLocation W20410472891 @default.
- W2041047289 hasLocation W20410472892 @default.
- W2041047289 hasOpenAccess W2041047289 @default.
- W2041047289 hasPrimaryLocation W20410472891 @default.
- W2041047289 hasRelatedWork W1970895070 @default.
- W2041047289 hasRelatedWork W1971010738 @default.
- W2041047289 hasRelatedWork W1980617967 @default.
- W2041047289 hasRelatedWork W1999232590 @default.
- W2041047289 hasRelatedWork W2016073646 @default.
- W2041047289 hasRelatedWork W2021789029 @default.
- W2041047289 hasRelatedWork W2041047289 @default.
- W2041047289 hasRelatedWork W2044022171 @default.
- W2041047289 hasRelatedWork W2053846799 @default.
- W2041047289 hasRelatedWork W2090999728 @default.
- W2041047289 hasVolume "368" @default.
- W2041047289 isParatext "false" @default.
- W2041047289 isRetracted "false" @default.
- W2041047289 magId "2041047289" @default.
- W2041047289 workType "article" @default.