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- W2041052186 abstract "To identify predictive factors for severe late toxicity after treatment with concomitant cisplatin and hyperfractionated radiotherapy or hyperfractionated radiotherapy alone in locally advanced head and neck cancer. Patients were analyzed from the previously reported Phase III trial SAKK 10/94. Severe late toxicity was defined as late RTOG Grade 3 or 4 dysphagia, xerostomia, soft tissue fibrosis, mucosal atrophy, laryngitis or bone necrosis, and/or potential treatment-related death within three years of randomization. Univariable and multivariable Cox regression analyses were performed. A total of 213 of 224 randomized patients were analyzed for this study (no data available three months after radiotherapy for the remaining patients). Median follow-up was 9.7 years (range, 0.4 – 15.4 years). Forty percent of the analyzed patients experienced severe late toxicity. In multivariable analyses, cN2 – 3 disease [Hazard ratio (HR): 1.95 (95% Confidence interval (CI): 1.2, 3.17; p = 0.007)], RTOG Grade 3 – 4 acute dysphagia [HR: 2.92 (95% CI, 1.75, 4.88; p < 0.0001)] and lower weight loss ratio (> 3% weight loss in the six months before treatment) [HR: 2.02 (95% CI, 1.26, 3.23; p = 0.003)] were associated with increased severe late toxicity while hemoglobin level < 14 g/dL before treatment [HR: 0.58 (95% CI, 0.36, 0.93; p = 0.025)] and technically resectable disease at trial entry [HR: 0.60 (95% CI, 0.38, 0.97; p = 0.036)] were associated with decreased severe late toxicity. Chemotherapy did not appear to affect late toxicity. Advanced N-classification, severe acute dysphagia, lower weight loss ratio, lower hemoglobin level and technically operable disease appear to be independent factors to predict late toxicity after hyperfractionated radiotherapy alone or with concomitant chemotherapy." @default.
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- W2041052186 date "2011-10-01" @default.
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- W2041052186 title "Predictors of Severe Late Toxicity after Hyperfractionated Radiotherapy with or without Concomitant Cisplatin in Locally Advanced Head and Neck Cancer: Results of a Randomized Phase III Trial (SAKK 10/94)" @default.
- W2041052186 doi "https://doi.org/10.1016/j.ijrobp.2011.06.1687" @default.
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