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• W2041054640 abstract "A series of Neurospora crassa mutants affected in the ability to regulate entry into conidiation (an asexual developmental program) were isolated by using an insertional mutagenesis procedure followed by a screening protocol. One of the mutants isolated by this approach consisted entirely of cells with an abnormal morphology. The mutant produces chains of swollen septated cells. The developmentally regulated ccg-1 gene is constitutively expressed in these cells, suggesting that they have entered the conidial developmental program. The insertionally disrupted gene cnb-1 was isolated by plasmid rescue and found to encode calcineurin B, the regulatory subunit of the Ca2+ and calmodulin-dependent protein phosphatase calcineurin. The data demonstrate that calcineurin B is required for normal vegetative growth in N. crassa and suggest that the cnb-1 mutant is unable to repress entry into the asexual developmental program. The results suggest that Ca2+ may play an important role in regulating fungal morphology." @default.
• W2041054640 created "2016-06-24" @default.
• W2041054640 creator A5019759690 @default.
• W2041054640 creator A5075741902 @default.
• W2041054640 date "1998-04-01" @default.
• W2041054640 modified "2023-10-09" @default.
• W2041054640 title "Calcineurin Subunit B Is Required for Normal Vegetative Growth inNeurospora crassa" @default.
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• W2041054640 doi "https://doi.org/10.1006/fgbi.1998.1037" @default.
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