FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041063304> ?p ?o ?g. }

• W2041063304 endingPage "216" @default.
• W2041063304 startingPage "209" @default.
• W2041063304 abstract "Febrile infection-related epilepsy syndrome (FIRES) is a severe postinfectious epileptic encephalopathy in previously healthy children and has three phases: the initial phase with a simple febrile infection, a few days later the acute phase characterized by a peracute onset of highly recurrent seizures or refractory status epilepticus often with no more fever and generally without additional neurological features (the classical pure seizure phenotype), and last, the chronic phase with a drug-resistant epilepsy and neuropsychological impairments. FIRES seems to be sporadic and very rare: we estimated the annual incidence in children and adolescents by a prospective hospital-based German-wide surveillance as 1 in 1,000,000. Because of the preceding infection and lacking evidence of infectious encephalitis, an immune-mediated pathomechanism and, therefore, a response to immunotherapies may be involved. To test the hypothesis that antibodies against neuronal structures cause FIRES, we analyzed sera of 12 patients aged 2 to 12 years (median 6 years) and cerebral spinal fluids (CSFs) of 3 of these 12 patients with acute or chronic FIRES. We studied six patients (two including CSF) 1 to 14 weeks (median 3 weeks) and six patients 1 to 6 years (median 3.5 years) after seizure onset. All samples were analyzed for antibodies against glutamate receptors of type N-methyl-D-aspartate (NMDA) and type α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA), gamma-aminobutyric acid (GABA)_B-receptors, voltage-gated potassium channel (VGKC)-associated proteins leucin-rich glioma inactivated 1 (LGI1) and contactin-associated protein like 2 (CASPR2), and glutamic acid decarboxylase (GAD) by a multiparametric recombinant immunofluorescence assay employing human embryonic kidney (HEK) cells transfected with cDNAs for the antigens. In addition, indirect immunohistochemistry using rat whole-brain sections was done in three patients. Finally, sera of 10 patients were tested for VGKC complex antibodies by radioimmunoprecipitation assay (RIA). None of the antibody tests were positive in any of the patients. Moreover, steroids, immunoglobulins, and plasmapheresis had no clear effect in the seven patients receiving immunotherapy. The failure of antibody-detection against the known neuronal antigens as well as the ineffectiveness of immunotherapy questions a role for autoantibodies in the epileptogenesis of classical FIRES. As we discuss, other underlying causes need to be considered including the possibility of a mitochondrial encephalopathy." @default.
• W2041063304 created "2016-06-24" @default.
• W2041063304 creator A5013168625 @default.
• W2041063304 creator A5024920607 @default.
• W2041063304 creator A5039404447 @default.
• W2041063304 creator A5041942422 @default.
• W2041063304 creator A5062939642 @default.
• W2041063304 creator A5065785358 @default.
• W2041063304 creator A5066086409 @default.
• W2041063304 creator A5072398131 @default.
• W2041063304 creator A5074695558 @default.
• W2041063304 creator A5081618280 @default.
• W2041063304 creator A5082543715 @default.
• W2041063304 creator A5082706638 @default.
• W2041063304 creator A5089529412 @default.
• W2041063304 date "2012-08-01" @default.
• W2041063304 modified "2023-10-18" @default.
• W2041063304 title "Febrile Infection-Related Epilepsy Syndrome without Detectable Autoantibodies and Response to Immunotherapy: A Case Series and Discussion of Epileptogenesis in FIRES" @default.
• W2041063304 doi "https://doi.org/10.1055/s-0032-1323848" @default.
• W2041063304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22911482" @default.
• W2041063304 hasPublicationYear "2012" @default.
• W2041063304 type Work @default.
• W2041063304 sameAs 2041063304 @default.
• W2041063304 citedByCount "66" @default.
• W2041063304 countsByYear W20410633042013 @default.
• W2041063304 countsByYear W20410633042014 @default.
• W2041063304 countsByYear W20410633042015 @default.
• W2041063304 countsByYear W20410633042016 @default.
• W2041063304 countsByYear W20410633042017 @default.
• W2041063304 countsByYear W20410633042018 @default.
• W2041063304 countsByYear W20410633042019 @default.
• W2041063304 countsByYear W20410633042020 @default.
• W2041063304 countsByYear W20410633042021 @default.
• W2041063304 countsByYear W20410633042022 @default.
• W2041063304 countsByYear W20410633042023 @default.
• W2041063304 crossrefType "journal-article" @default.
• W2041063304 hasAuthorship W2041063304A5013168625 @default.
• W2041063304 hasAuthorship W2041063304A5024920607 @default.
• W2041063304 hasAuthorship W2041063304A5039404447 @default.
• W2041063304 hasAuthorship W2041063304A5041942422 @default.
• W2041063304 hasAuthorship W2041063304A5062939642 @default.
• W2041063304 hasAuthorship W2041063304A5065785358 @default.
• W2041063304 hasAuthorship W2041063304A5066086409 @default.
• W2041063304 hasAuthorship W2041063304A5072398131 @default.
• W2041063304 hasAuthorship W2041063304A5074695558 @default.
• W2041063304 hasAuthorship W2041063304A5081618280 @default.
• W2041063304 hasAuthorship W2041063304A5082543715 @default.
• W2041063304 hasAuthorship W2041063304A5082706638 @default.
• W2041063304 hasAuthorship W2041063304A5089529412 @default.
• W2041063304 hasConcept C118552586 @default.
• W2041063304 hasConcept C126322002 @default.
• W2041063304 hasConcept C159654299 @default.
• W2041063304 hasConcept C163764329 @default.
• W2041063304 hasConcept C187212893 @default.
• W2041063304 hasConcept C203014093 @default.
• W2041063304 hasConcept C2522874641 @default.
• W2041063304 hasConcept C2777341932 @default.
• W2041063304 hasConcept C2777701055 @default.
• W2041063304 hasConcept C2778186239 @default.
• W2041063304 hasConcept C2780874087 @default.
• W2041063304 hasConcept C57236427 @default.
• W2041063304 hasConcept C71924100 @default.
• W2041063304 hasConcept C83455156 @default.
• W2041063304 hasConcept C8891405 @default.
• W2041063304 hasConceptScore W2041063304C118552586 @default.
• W2041063304 hasConceptScore W2041063304C126322002 @default.
• W2041063304 hasConceptScore W2041063304C159654299 @default.
• W2041063304 hasConceptScore W2041063304C163764329 @default.
• W2041063304 hasConceptScore W2041063304C187212893 @default.
• W2041063304 hasConceptScore W2041063304C203014093 @default.
• W2041063304 hasConceptScore W2041063304C2522874641 @default.
• W2041063304 hasConceptScore W2041063304C2777341932 @default.
• W2041063304 hasConceptScore W2041063304C2777701055 @default.
• W2041063304 hasConceptScore W2041063304C2778186239 @default.
• W2041063304 hasConceptScore W2041063304C2780874087 @default.
• W2041063304 hasConceptScore W2041063304C57236427 @default.
• W2041063304 hasConceptScore W2041063304C71924100 @default.
• W2041063304 hasConceptScore W2041063304C83455156 @default.
• W2041063304 hasConceptScore W2041063304C8891405 @default.
• W2041063304 hasIssue "04" @default.
• W2041063304 hasLocation W20410633041 @default.
• W2041063304 hasLocation W20410633042 @default.
• W2041063304 hasOpenAccess W2041063304 @default.
• W2041063304 hasPrimaryLocation W20410633041 @default.
• W2041063304 hasRelatedWork W1975614538 @default.
• W2041063304 hasRelatedWork W2042291251 @default.
• W2041063304 hasRelatedWork W2043045967 @default.
• W2041063304 hasRelatedWork W2054102848 @default.
• W2041063304 hasRelatedWork W2314058386 @default.
• W2041063304 hasRelatedWork W2412241457 @default.
• W2041063304 hasRelatedWork W2945163262 @default.
• W2041063304 hasRelatedWork W4205234895 @default.
• W2041063304 hasRelatedWork W4225006941 @default.
• W2041063304 hasRelatedWork W3111377143 @default.
• W2041063304 hasVolume "43" @default.
• W2041063304 isParatext "false" @default.
• W2041063304 isRetracted "false" @default.
• W2041063304 magId "2041063304" @default.

• next