FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041075406> ?p ?o ?g. }

• W2041075406 endingPage "1777" @default.
• W2041075406 startingPage "1774" @default.
• W2041075406 abstract "Endothelium-derived relaxing factor has been recently identified as nitric oxide. The purpose of this study was to determine if vasodilator drugs that generate nitric oxide inhibit vascular smooth muscle mitogenesis and proliferation in culture. Three chemically dissimilar vasodilators, sodium nitroprusside, S-nitroso-N-acetylpenicillamine and isosorbide dinitrate, dose-dependently inhibited serum-induced thymidine incorporation by rat aortic smooth muscle cells. Moreover, 8-bromo-cGMP mimicked the antimitogenic effect of the nitric oxide-generating drugs. The antimitogenic effect of S-nitroso-N-acetylpenicillamine was inhibited by hemoglobin and potentiated by superoxide dismutase, supporting the view that nitric oxide was the ultimate effector. Sodium nitroprusside and S-nitroso-N-acetylpenicillamine significantly decreased the proliferation of vascular smooth muscle cells. Moreover, the inhibition of mitogenesis and proliferation was shown to be independent of cell damage, as documented by several criteria of cell viability. These results suggest that endogenous nitric oxide may function as a modulator of vascular smooth muscle cell mitogenesis and proliferation, by a cGMP-mediated mechanism." @default.
• W2041075406 created "2016-06-24" @default.
• W2041075406 creator A5068483131 @default.
• W2041075406 creator A5075494047 @default.
• W2041075406 date "1989-05-01" @default.
• W2041075406 modified "2023-10-16" @default.
• W2041075406 title "Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells." @default.
• W2041075406 cites W153662504 @default.
• W2041075406 cites W176913255 @default.
• W2041075406 cites W1838917319 @default.
• W2041075406 cites W1907994445 @default.
• W2041075406 cites W1969210400 @default.
• W2041075406 cites W1994870607 @default.
• W2041075406 cites W1996003434 @default.
• W2041075406 cites W1999815931 @default.
• W2041075406 cites W2007737411 @default.
• W2041075406 cites W2037684420 @default.
• W2041075406 cites W2048635427 @default.
• W2041075406 cites W2057960696 @default.
• W2041075406 cites W2061509201 @default.
• W2041075406 cites W2085749356 @default.
• W2041075406 cites W2090636881 @default.
• W2041075406 cites W2091632618 @default.
• W2041075406 cites W2092145002 @default.
• W2041075406 cites W2142975032 @default.
• W2041075406 cites W2156838463 @default.
• W2041075406 cites W2266355647 @default.
• W2041075406 cites W2304337690 @default.
• W2041075406 cites W2413171618 @default.
• W2041075406 cites W2430954621 @default.
• W2041075406 cites W51148016 @default.
• W2041075406 doi "https://doi.org/10.1172/jci114081" @default.
• W2041075406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303890" @default.
• W2041075406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2540223" @default.
• W2041075406 hasPublicationYear "1989" @default.
• W2041075406 type Work @default.
• W2041075406 sameAs 2041075406 @default.
• W2041075406 citedByCount "2083" @default.
• W2041075406 countsByYear W20410754062012 @default.
• W2041075406 countsByYear W20410754062013 @default.
• W2041075406 countsByYear W20410754062014 @default.
• W2041075406 countsByYear W20410754062015 @default.
• W2041075406 countsByYear W20410754062016 @default.
• W2041075406 countsByYear W20410754062017 @default.
• W2041075406 countsByYear W20410754062018 @default.
• W2041075406 countsByYear W20410754062019 @default.
• W2041075406 countsByYear W20410754062020 @default.
• W2041075406 countsByYear W20410754062021 @default.
• W2041075406 countsByYear W20410754062022 @default.
• W2041075406 countsByYear W20410754062023 @default.
• W2041075406 crossrefType "journal-article" @default.
• W2041075406 hasAuthorship W2041075406A5068483131 @default.
• W2041075406 hasAuthorship W2041075406A5075494047 @default.
• W2041075406 hasBestOaLocation W20410754061 @default.
• W2041075406 hasConcept C120770815 @default.
• W2041075406 hasConcept C121684516 @default.
• W2041075406 hasConcept C126322002 @default.
• W2041075406 hasConcept C134018914 @default.
• W2041075406 hasConcept C185592680 @default.
• W2041075406 hasConcept C2776992346 @default.
• W2041075406 hasConcept C2778949068 @default.
• W2041075406 hasConcept C2779395532 @default.
• W2041075406 hasConcept C2779610285 @default.
• W2041075406 hasConcept C2779997099 @default.
• W2041075406 hasConcept C2780310817 @default.
• W2041075406 hasConcept C2780994212 @default.
• W2041075406 hasConcept C2992686903 @default.
• W2041075406 hasConcept C41008148 @default.
• W2041075406 hasConcept C519581460 @default.
• W2041075406 hasConcept C55493867 @default.
• W2041075406 hasConcept C62112901 @default.
• W2041075406 hasConcept C71924100 @default.
• W2041075406 hasConcept C86803240 @default.
• W2041075406 hasConcept C98274493 @default.
• W2041075406 hasConceptScore W2041075406C120770815 @default.
• W2041075406 hasConceptScore W2041075406C121684516 @default.
• W2041075406 hasConceptScore W2041075406C126322002 @default.
• W2041075406 hasConceptScore W2041075406C134018914 @default.
• W2041075406 hasConceptScore W2041075406C185592680 @default.
• W2041075406 hasConceptScore W2041075406C2776992346 @default.
• W2041075406 hasConceptScore W2041075406C2778949068 @default.
• W2041075406 hasConceptScore W2041075406C2779395532 @default.
• W2041075406 hasConceptScore W2041075406C2779610285 @default.
• W2041075406 hasConceptScore W2041075406C2779997099 @default.
• W2041075406 hasConceptScore W2041075406C2780310817 @default.
• W2041075406 hasConceptScore W2041075406C2780994212 @default.
• W2041075406 hasConceptScore W2041075406C2992686903 @default.
• W2041075406 hasConceptScore W2041075406C41008148 @default.
• W2041075406 hasConceptScore W2041075406C519581460 @default.
• W2041075406 hasConceptScore W2041075406C55493867 @default.
• W2041075406 hasConceptScore W2041075406C62112901 @default.
• W2041075406 hasConceptScore W2041075406C71924100 @default.
• W2041075406 hasConceptScore W2041075406C86803240 @default.
• W2041075406 hasConceptScore W2041075406C98274493 @default.
• W2041075406 hasIssue "5" @default.
• W2041075406 hasLocation W20410754061 @default.
• W2041075406 hasLocation W20410754062 @default.
• W2041075406 hasLocation W20410754063 @default.

• next