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• W2041076906 abstract "Despite standard surgical,1-4 radiotherapeutic5-15 and more innovative approaches including intraoperative radiation therapy (brachytherapy and electrons), 6,13,15,16-24 high linear energy transfer (LET) radiation,26-2g hyperthermia,30 and radiosensitizers,2i pancreatic carcinoma remains an almost universally fatal disease. Although median survivals as long as 40 months have been reported in selected Stage I and II patients undergoing curative surgery3 and 19 months in selected patients with unresectable carcinoma who receive external beam and intraoperative radiation therapy with electrons,21 most series report a median survival of 7 to 12 months and histologically proven five year survivors are anecdotal. Although the primary goal is to influence survival, the fact remains that the vast majority of patients do not survive more than a few years and many experience an extraordinary painful death. For patients with pancreatic carcinoma, therefore, similar to many other gastrointestinal malignancies, the quality of life is an important factor. Pain is a common presenting symptom of pancreatic carcinoma. In a retrospective analysis of 393 patients who were entered into pancreatric carcinoma protocols of the GITSG,31 79% presented with pain. The pain was present in the abdomen in 35%, back in S%, and the abdomen and back in 36%. The overall incidence of pain was a function of the tumor stage. In a group of 100 patients with limited disease who were able to undergo a complete resection, 33% presented with pain. In a group of 182 patients with locally advanced carcinoma" @default.
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• W2041076906 date "1988-01-01" @default.
• W2041076906 modified "2023-09-25" @default.
• W2041076906 title "The role of radiation therapy in the control of pain from pancreatic carcinoma" @default.
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• W2041076906 doi "https://doi.org/10.1016/0885-3924(88)90031-0" @default.
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