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• W2041103655 abstract "Mirror movements are involuntary symmetrical movements of one side of the body that mirror voluntary movements of the other side. Congenital mirror movement disorder is a rare condition characterized by mirror movements that persist throughout adulthood in subjects with no other clinical abnormalities. The affected individuals have mirror movements predominating in the muscles that control the fingers and are unable to perform purely unimanual movements. Congenital mirror movement disorder thus provides a unique paradigm for studying the lateralization of motor control. We conducted a multimodal, controlled study of patients with congenital mirror movements associated with RAD51 haploinsufficiency (n = 7, mean age 33.3 ± 16.8 years) by comparison with age- and gender-matched healthy volunteers (n = 14, mean age 33.9 ± 16.1 years). We showed that patients with congenital mirror movements induced by RAD51 deficiency had: (i) an abnormal decussation of the corticospinal tract; (ii) abnormal interhemispheric inhibition and bilateral cortical activation of primary motor areas during intended unimanual movements; and (iii) an abnormal involvement of the supplementary motor area during both unimanual and bimanual movements. The lateralization of motor control thus requires a fine interplay between interhemispheric communication and corticospinal wiring. This fine interplay determines: (i) the delivery of appropriate motor plans from the supplementary motor area to the primary motor cortex; (ii) the lateralized activation of the primary motor cortex; and (iii) the unilateral transmission of the motor command to the limb involved in the intended movement. Our results also unveil an unexpected function of RAD51 in corticospinal development of the motor system." @default.
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• W2041103655 date "2013-09-20" @default.
• W2041103655 modified "2023-10-17" @default.
• W2041103655 title "RAD51 deficiency disrupts the corticospinal lateralization of motor control" @default.
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• W2041103655 cites W1979322342 @default.
• W2041103655 cites W1979354600 @default.
• W2041103655 cites W1980233301 @default.
• W2041103655 cites W1989491127 @default.
• W2041103655 cites W1993074412 @default.
• W2041103655 cites W1994229359 @default.
• W2041103655 cites W1997148097 @default.
• W2041103655 cites W1997975445 @default.
• W2041103655 cites W2000161680 @default.
• W2041103655 cites W2003539800 @default.
• W2041103655 cites W2003787873 @default.
• W2041103655 cites W2005849715 @default.
• W2041103655 cites W2006419171 @default.
• W2041103655 cites W2008808210 @default.
• W2041103655 cites W2009610621 @default.
• W2041103655 cites W2011572057 @default.
• W2041103655 cites W2012979514 @default.
• W2041103655 cites W2018566432 @default.
• W2041103655 cites W2018868748 @default.
• W2041103655 cites W2021397391 @default.
• W2041103655 cites W2024450174 @default.
• W2041103655 cites W2026026008 @default.
• W2041103655 cites W2031392589 @default.
• W2041103655 cites W2044962914 @default.
• W2041103655 cites W2049162638 @default.
• W2041103655 cites W2059865840 @default.
• W2041103655 cites W2059979363 @default.
• W2041103655 cites W2060899536 @default.
• W2041103655 cites W2061196115 @default.
• W2041103655 cites W2064979714 @default.
• W2041103655 cites W2068585955 @default.
• W2041103655 cites W2069474677 @default.
• W2041103655 cites W2077037443 @default.
• W2041103655 cites W2077869186 @default.
• W2041103655 cites W2078216073 @default.
• W2041103655 cites W2082211636 @default.
• W2041103655 cites W2082543168 @default.
• W2041103655 cites W2090643725 @default.
• W2041103655 cites W2091219829 @default.
• W2041103655 cites W2093972428 @default.
• W2041103655 cites W2096695639 @default.
• W2041103655 cites W2099338076 @default.
• W2041103655 cites W2104620926 @default.
• W2041103655 cites W2106421497 @default.
• W2041103655 cites W2108274163 @default.
• W2041103655 cites W2118740630 @default.
• W2041103655 cites W2121680149 @default.
• W2041103655 cites W2126404651 @default.
• W2041103655 cites W2127800088 @default.
• W2041103655 cites W2135963093 @default.
• W2041103655 cites W2136812771 @default.
• W2041103655 cites W2142061972 @default.
• W2041103655 cites W2142373488 @default.
• W2041103655 cites W2148344940 @default.
• W2041103655 cites W2150773709 @default.
• W2041103655 cites W2167015445 @default.
• W2041103655 cites W2169240629 @default.
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• W2041103655 doi "https://doi.org/10.1093/brain/awt258" @default.
• W2041103655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24056534" @default.
• W2041103655 hasPublicationYear "2013" @default.
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