FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041107344> ?p ?o ?g. }

• W2041107344 endingPage "564" @default.
• W2041107344 startingPage "555" @default.
• W2041107344 abstract "Aluminium fluoride (AlF4-), a G protein activator, was used to study a possible role of G protein in the control of the pathways for Ca2+ influx through plasma membrane of human carcinoma A431 cells. Fluorimetric measurements with the Ca2+ indicator Indo-1 have shown that addition of fluoride induces an increase in concentration of cytosolic free calcium ([Ca2+]in) due to both release of Ca2+ from intracellular stores and Ca2+ influx from the extracellular medium. The cells stimulated by fluoride became unresponsive to subsequent addition of epidermal growth factor (EGF), histamine and bradykinin. The Ca2+ signal induced by fluoride as well as one induced by EGF was inhibited by the pretreatment of cells with protein kinase C activator, phorbol myristate acetate (PMA). The pretreatment of the cells with pertussis toxin produced no effect on EGF-induced calcium response. In contrast, the pretreatment with cholera toxin (CTX) increased the basal level of [Ca2+]in and abolished the effect of EGF. The effects of CTX could not be reproduced by treating the cells with forskolin or IBMX, agents known to elevate cAMP content in the cell. Patch clamp experiments have shown that fluoride increases the activity of Ca(2+)-permeable channels identical to those activated by EGF from the extracellular side of the membrane [Mozhayeva et al. (1991) J. Membr. Biol. 124, 113-126]. The results obtained suggest the involvement of GTP-binding protein in signal transduction from the EGF receptor to Ca(2+)-permeable channel of plasma membrane in A431 cells." @default.
• W2041107344 created "2016-06-24" @default.
• W2041107344 creator A5021204262 @default.
• W2041107344 creator A5039847278 @default.
• W2041107344 creator A5043396006 @default.
• W2041107344 creator A5074154702 @default.
• W2041107344 date "1993-09-01" @default.
• W2041107344 modified "2023-10-16" @default.
• W2041107344 title "Evidence for involvement of a GTP-binding protein in activation of Ca2+ influx by epidermal growth factor in A431 cells: Effects of fluoride and bacterial toxins" @default.
• W2041107344 cites W1490475005 @default.
• W2041107344 cites W1490925016 @default.
• W2041107344 cites W1495442004 @default.
• W2041107344 cites W1498793897 @default.
• W2041107344 cites W1519709368 @default.
• W2041107344 cites W1527715380 @default.
• W2041107344 cites W1553151363 @default.
• W2041107344 cites W1560653093 @default.
• W2041107344 cites W1586275583 @default.
• W2041107344 cites W1786279927 @default.
• W2041107344 cites W1972041630 @default.
• W2041107344 cites W1985334766 @default.
• W2041107344 cites W1990865815 @default.
• W2041107344 cites W1994063448 @default.
• W2041107344 cites W1996626314 @default.
• W2041107344 cites W2006837023 @default.
• W2041107344 cites W2009667219 @default.
• W2041107344 cites W2012502024 @default.
• W2041107344 cites W2017100096 @default.
• W2041107344 cites W2017671824 @default.
• W2041107344 cites W2023363801 @default.
• W2041107344 cites W2030383799 @default.
• W2041107344 cites W2032359283 @default.
• W2041107344 cites W2034368055 @default.
• W2041107344 cites W2039531779 @default.
• W2041107344 cites W2042760229 @default.
• W2041107344 cites W2044897724 @default.
• W2041107344 cites W2060426330 @default.
• W2041107344 cites W2063676527 @default.
• W2041107344 cites W2080875376 @default.
• W2041107344 cites W2094053094 @default.
• W2041107344 cites W2106988040 @default.
• W2041107344 cites W2141260882 @default.
• W2041107344 cites W2339914993 @default.
• W2041107344 cites W2341560794 @default.
• W2041107344 cites W2799503982 @default.
• W2041107344 cites W4249422537 @default.
• W2041107344 cites W49251375 @default.
• W2041107344 cites W2005671176 @default.
• W2041107344 doi "https://doi.org/10.1016/0898-6568(93)90051-m" @default.
• W2041107344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8312133" @default.
• W2041107344 hasPublicationYear "1993" @default.
• W2041107344 type Work @default.
• W2041107344 sameAs 2041107344 @default.
• W2041107344 citedByCount "12" @default.
• W2041107344 countsByYear W20411073442012 @default.
• W2041107344 countsByYear W20411073442014 @default.
• W2041107344 crossrefType "journal-article" @default.
• W2041107344 hasAuthorship W2041107344A5021204262 @default.
• W2041107344 hasAuthorship W2041107344A5039847278 @default.
• W2041107344 hasAuthorship W2041107344A5043396006 @default.
• W2041107344 hasAuthorship W2041107344A5074154702 @default.
• W2041107344 hasConcept C134018914 @default.
• W2041107344 hasConcept C1491633281 @default.
• W2041107344 hasConcept C163235415 @default.
• W2041107344 hasConcept C170493617 @default.
• W2041107344 hasConcept C178790620 @default.
• W2041107344 hasConcept C184235292 @default.
• W2041107344 hasConcept C185592680 @default.
• W2041107344 hasConcept C195794163 @default.
• W2041107344 hasConcept C2776362946 @default.
• W2041107344 hasConcept C2777006276 @default.
• W2041107344 hasConcept C2779276759 @default.
• W2041107344 hasConcept C28406088 @default.
• W2041107344 hasConcept C29537977 @default.
• W2041107344 hasConcept C47170353 @default.
• W2041107344 hasConcept C49773422 @default.
• W2041107344 hasConcept C519063684 @default.
• W2041107344 hasConcept C55493867 @default.
• W2041107344 hasConcept C62478195 @default.
• W2041107344 hasConcept C67082663 @default.
• W2041107344 hasConcept C80631254 @default.
• W2041107344 hasConcept C86803240 @default.
• W2041107344 hasConcept C88045685 @default.
• W2041107344 hasConcept C95444343 @default.
• W2041107344 hasConcept C97029542 @default.
• W2041107344 hasConceptScore W2041107344C134018914 @default.
• W2041107344 hasConceptScore W2041107344C1491633281 @default.
• W2041107344 hasConceptScore W2041107344C163235415 @default.
• W2041107344 hasConceptScore W2041107344C170493617 @default.
• W2041107344 hasConceptScore W2041107344C178790620 @default.
• W2041107344 hasConceptScore W2041107344C184235292 @default.
• W2041107344 hasConceptScore W2041107344C185592680 @default.
• W2041107344 hasConceptScore W2041107344C195794163 @default.
• W2041107344 hasConceptScore W2041107344C2776362946 @default.
• W2041107344 hasConceptScore W2041107344C2777006276 @default.
• W2041107344 hasConceptScore W2041107344C2779276759 @default.
• W2041107344 hasConceptScore W2041107344C28406088 @default.
• W2041107344 hasConceptScore W2041107344C29537977 @default.

• next