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• W2041128667 startingPage "721" @default.
• W2041128667 abstract "Ever since its discovery in 1953 by N. O. Kaplan and coworkers, the physiological role of the proton-translocating transhydrogenase has generally been assumed to be that of generating mitochondrial NADPH. Mitochondrial NADPH can be used in a number of important reactions/processes, e.g., biosynthesis, maintenance of GSH, apoptosis, aging etc. This assumed role has found some support in bacteria but not in higher eukaryotes, a situation which changed dramatically with two recent but separate findings, both using transhydrogenase knockouts, in the nematode C. elegans and the mouse strain C57BL/6J. The latter, which is due to a spontaneous deletion mutation in the Nnt gene, was serendipitously found during investigations of the diabetic properties of these mice. The implications of these findings for the overall role of transhydrogenase in cell metabolism and disease are discussed." @default.
• W2041128667 created "2016-06-24" @default.
• W2041128667 creator A5091204611 @default.
• W2041128667 date "2006-05-01" @default.
• W2041128667 modified "2023-10-05" @default.
• W2041128667 title "Mitochondrial NADPH, transhydrogenase and disease" @default.
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• W2041128667 doi "https://doi.org/10.1016/j.bbabio.2006.03.010" @default.
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